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CABLES1抗體,Rabbit Polyclonal CABLES1 Antibody
  • CABLES1抗體,Rabbit Polyclonal CABLES1 Antibody
  • CABLES1抗體,Rabbit Polyclonal CABLES1 Antibody
  • CABLES1抗體,Rabbit Polyclonal CABLES1 Antibody

CABLES1抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-14
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CABLES1抗體英文名稱:Rabbit Polyclonal CABLES1 Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 3927 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: CABLES1
2025-05-14 CABLES1抗體 Rabbit Polyclonal CABLES1 Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 3927 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCABL1; IK3-1; CABLES; HsT2563
WB Predicted band size68 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human CABLES1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 6%SDS-PAGE, Lysate: 40 μg, Lane 1-3: Mouse brain tissue, Mouse heart tissue, mouse liver tissue, Primary antibody: P08088(CABLES1 Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    


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       The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P08088(CABLES1 Antibody) at dilution 1/15. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P08088(CABLES1 Antibody) at dilution 1/15. (Original magnification: ×200)    


           

參考文獻

以下是關(guān)于CABLES1抗體的3篇參考文獻的簡要信息:

1. **文獻名稱**:*CABLES1. a cyclin-dependent kinase-interacting protein, is altered in human cancers*

**作者**:Sjoblom T, et al.

**摘要**:本研究通過基因組篩查發(fā)現(xiàn)CABLES1在結(jié)直腸癌中頻繁發(fā)生表達缺失或突變,利用CABLES1抗體進行免疫組化分析,證實其表達下調(diào)與腫瘤進展相關(guān),提示其作為潛在腫瘤抑制因子的作用。

2. **文獻名稱**:*CABLES1 links Wnt/β-catenin signaling to cell cycle regulation*

**作者**:Chen Y, et al.

**摘要**:文章報道CABLES1通過調(diào)控CDK3活性參與Wnt/β-catenin信號通路,使用CABLES1抗體進行免疫共沉淀實驗,證明其與β-catenin和CDK3形成復(fù)合物,影響細胞周期G1/S期轉(zhuǎn)換。

3. **文獻名稱**:*Loss of CABLES1 promotes glioblastoma invasiveness via EGFR signaling*

**作者**:Nakayama KI, et al.

**摘要**:研究通過Western blot和免疫熒光(使用CABLES1抗體)發(fā)現(xiàn)膠質(zhì)母細胞瘤中CABLES1表達缺失導(dǎo)致EGFR信號異常激活,進而增強腫瘤細胞侵襲性,提示其作為治療靶點的潛力。

(注:以上文獻為虛構(gòu)示例,實際引用需查詢具體數(shù)據(jù)庫。)

       

背景信息

CABLES1 (Cdk5 and Abl enzyme substrate 1) is a cell cycle regulatory protein encoded by the *CABLES1* gene located on chromosome 18q11.2. It belongs to the CABLES family of cyclin-dependent kinase (CDK)-interacting proteins and contains a conserved C-terminal domain that facilitates interactions with CDKs. CABLES1 functions as a tumor suppressor by modulating CDK activity, particularly through its binding to CDK3 and CDK5. and plays a role in cell cycle arrest, apoptosis, and DNA damage response. It also interacts with p53. enhancing its transcriptional activity to regulate cell fate decisions.

CABLES1 expression is frequently downregulated in various cancers, including colorectal, ovarian, and endometrial cancers, often due to promoter hypermethylation. Loss of CABLES1 is associated with poor prognosis and chemoresistance. Antibodies targeting CABLES1 are essential tools for studying its expression, localization, and functional roles in cellular pathways. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence to investigate CABLES1's involvement in tumor suppression, cell cycle dynamics, and therapeutic responses. Commercial CABLES1 antibodies are typically validated for specificity using knockout cell lines or siRNA-mediated knockdown to ensure accurate detection in both research and diagnostic contexts.

       
關(guān)鍵字: CABLES1抗體;CABLES1;CABLES1 Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (1年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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