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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P07577(RBMS2 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The RBMS2 antibody is a tool used to detect and study the RNA-binding motif single-stranded interacting protein 2 (RBMS2), a member of the RBMS family of nucleic acid-binding proteins. RBMS2 plays a critical role in post-transcriptional gene regulation by binding to RNA or single-stranded DNA, influencing processes such as RNA splicing, stability, and translation. It is implicated in various cellular functions, including cell proliferation, differentiation, and apoptosis. Dysregulation of RBMS2 has been linked to cancer progression, particularly in tumors like hepatocellular carcinoma, breast cancer, and colorectal cancer, where it may act as a tumor suppressor or oncogene depending on context.

The RBMS2 antibody is widely used in research applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), to assess protein expression levels and localization in tissues or cell lines. Its development typically involves immunizing hosts with purified RBMS2 protein fragments or synthetic peptides to generate polyclonal or monoclonal antibodies. Validation steps ensure specificity and reliability, often including knockout cell controls. Studying RBMS2 with this antibody provides insights into its molecular mechanisms, disease associations, and potential therapeutic targets. Researchers also explore its interactions with other proteins or RNA molecules to unravel its role in gene regulatory networks.