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TUBB抗體,Rabbit Polyclonal TUBB Antibody
  • TUBB抗體,Rabbit Polyclonal TUBB Antibody
  • TUBB抗體,Rabbit Polyclonal TUBB Antibody
  • TUBB抗體,Rabbit Polyclonal TUBB Antibody

TUBB抗體

價格 詢價
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-11
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:TUBB抗體英文名稱:Rabbit Polyclonal TUBB Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 2052 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Rabbit
偶聯(lián)物: 靶點: TUBB
2025-05-11 TUBB抗體 Rabbit Polyclonal TUBB Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 2052 year. Avoid repeated freeze / thaw cycles. 抗體

驗證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesM40; TUBB1; TUBB5; CDCBM6; OK/SW-cl.56
WB Predicted band size50 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: NIH/3T3, HEPG2, Hela and 293T cell, Mouse brain tissue lysates, Primary antibody: P01758(TUBB Antibody) at dilution 1/300, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P01758(TUBB Antibody) at dilution 1/30. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P01758(TUBB Antibody) at dilution 1/30. (Original magnification: ×200)    


           

參考文獻

以下是3篇關(guān)于TUBB抗體的參考文獻概覽(基于公開文獻特征概括,非真實引用):

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1. **文獻名稱**: *"TUBB3 overexpression as a biomarker of paclitaxel resistance in ovarian cancer"*

**作者**: Smith J. et al.

**摘要**: 研究揭示了TUBB3(βIII-tubulin)在卵巢癌細胞中的過表達與紫杉醇化療耐藥性的相關(guān)性,通過免疫組化實驗證實TUBB抗體可作為預(yù)測化療反應(yīng)的生物標(biāo)志物。

2. **文獻名稱**: *"Aberrant microtubule dynamics in Alzheimer’s disease: Role of TUBB phosphorylation"*

**作者**: Chen L. & Wang H.

**摘要**: 探討了阿爾茨海默病患者腦組織中TUBB蛋白異常磷酸化導(dǎo)致的微管穩(wěn)定性下降,使用TUBB特異性抗體檢測到神經(jīng)元內(nèi)微管結(jié)構(gòu)紊亂,提示其與tau蛋白病理的關(guān)聯(lián)。

3. **文獻名稱**: *"Development of a monoclonal antibody targeting TUBB for cancer immunotherapy"*

**作者**: Rodriguez M. et al.

**摘要**: 報道了一種新型抗TUBB單克隆抗體的開發(fā)與表征,該抗體通過靶向腫瘤細胞中異常表達的TUBB亞型,在體外實驗中顯示出抑制腫瘤細胞遷移和增殖的潛力。

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*注:以上為模擬示例,實際文獻需通過PubMed/Google Scholar等平臺檢索。建議使用關(guān)鍵詞 "TUBB antibody" + "cancer/therapeutic/neurodegeneration" 篩選近年高被引論文。*

       

背景信息

**Background of TUBB Antibodies**

TUBB antibodies target β-tubulin, a core component of microtubules, which are cytoskeletal polymers essential for cell structure, division, intracellular transport, and signaling. β-tubulin, along with α-tubulin, forms heterodimers that polymerize into dynamic microtubules. Mammals express multiple β-tubulin isotypes (e.g., TUBB1. TUBB2. TUBB3), each encoded by distinct genes and exhibiting tissue-specific expression or functional specialization. For example, TUBB3 is enriched in neurons and associated with axon guidance, while TUBB2A/B are broadly expressed in proliferating cells.

TUBB antibodies are widely used in research to study microtubule dynamics, cell cycle regulation, and diseases linked to tubulin dysfunction, such as cancer, neurodevelopmental disorders, and neurodegenerative conditions (e.g., Alzheimer’s disease). These antibodies enable the detection of β-tubulin expression levels, post-translational modifications (e.g., acetylation, tyrosination), and subcellular localization via techniques like Western blot, immunofluorescence, and immunohistochemistry.

Notably, certain TUBB isoforms are biomarkers for pathological states. TUBB3 overexpression, for instance, correlates with drug resistance in cancers treated with microtubule-targeting agents (e.g., taxanes). Conversely, mutations in TUBB genes disrupt microtubule stability, leading to malformations in brain development. Researchers must validate TUBB antibodies for specificity due to high sequence homology among isoforms and potential cross-reactivity. Overall, TUBB antibodies remain critical tools for exploring microtubule biology and its implications in health and disease.

       
關(guān)鍵字: TUBB抗體;TUBB;TUBB Antibody;

公司簡介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (2年) 注冊資本 50萬(元)
員工人數(shù) 1-10人 年營業(yè)額 ¥ 100萬以內(nèi)
主營行業(yè) 中間體,化學(xué)試劑 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:2年
  • 注冊資本:50萬(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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