中文名稱:PRPH抗體 | 英文名稱:Rabbit Polyclonal PRPH Antibody |
品牌: 艾普蒂 | 產(chǎn)地: 武漢 |
保存條件: Stored at -20°C for 1737 year. Avoid repeated freeze / thaw cycles. | 產(chǎn)品類別: 抗體 |
重組: 否 | 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA |
種屬反應(yīng)性: Human,Mouse,Rat | 宿主: Rabbit |
偶聯(lián)物: 無(wú) | 靶點(diǎn): PRPH |
WB | 咨詢技術(shù) | Human,Mouse,Rat |
IF | 咨詢技術(shù) | Human,Mouse,Rat |
IHC | 1/25-1/100 | Human,Mouse,Rat |
ICC | 技術(shù)咨詢 | Human,Mouse,Rat |
FCM | 咨詢技術(shù) | Human,Mouse,Rat |
Elisa | 1/500-1/1000 | Human,Mouse,Rat |
Aliases | NEF4; PRPH1 |
WB Predicted band size | 54 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Fusion protein of human PRPH |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cell lysate, Primary antibody: P00622(PRPH Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 9 minutes
The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00622(PRPH Antibody) at dilution 1/20. (Original magnification: ×200)
The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P00622(PRPH Antibody) at dilution 1/20. (Original magnification: ×200)
以下是關(guān)于PRPH(Peripherin)抗體的3篇代表性文獻(xiàn)摘要:
1. **文獻(xiàn)名稱**:*Autoantibodies to peripherin in patients with autoimmune neuropathy*
**作者**:Yan WX, et al.
**摘要**:研究發(fā)現(xiàn)PRPH抗體可能與自身免疫性神經(jīng)病變相關(guān),患者血清中檢測(cè)到抗peripherin抗體,提示其可能參與周?chē)窠?jīng)軸突損傷的免疫機(jī)制。
2. **文獻(xiàn)名稱**:*Peripherin as a biomarker for amyotrophic lateral sclerosis*
**作者**:Robertson J, et al.
**摘要**:探討peripherin在肌萎縮側(cè)索硬化癥(ALS)中的異常聚集現(xiàn)象,研究發(fā)現(xiàn)PRPH抗體可特異性標(biāo)記患者神經(jīng)元中的病理蛋白沉積,提示其作為疾病生物標(biāo)志物的潛力。
3. **文獻(xiàn)名稱**:*Differential expression of peripherin isoforms in neurological disorders*
**作者**:Larivière RC, et al.
**摘要**:分析PRPH不同異構(gòu)體在神經(jīng)退行性疾病中的表達(dá)差異,通過(guò)特異性抗體檢測(cè)發(fā)現(xiàn)某些異構(gòu)體在阿爾茨海默病和帕金森病中異常上調(diào),可能與疾病進(jìn)展相關(guān)。
注:以上文獻(xiàn)為示例,實(shí)際引用需根據(jù)具體研究領(lǐng)域核實(shí)(如神經(jīng)科學(xué)、自身免疫疾病等)。建議通過(guò)PubMed或Google Scholar以關(guān)鍵詞"peripherin antibody"+"disease"檢索最新研究。
PRPH antibodies target peripherin, a type III intermediate filament protein primarily expressed in neurons of the peripheral nervous system (PNS) and subsets of central nervous system (CNS) neurons. Peripherin plays a structural role in maintaining neuronal integrity, axon outgrowth, and intracellular transport. Its dysregulation has been linked to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and Charcot-Marie-Tooth neuropathy.
PRPH antibodies are of interest in both research and clinical contexts. In research, they serve as tools to study peripherin's function, localization, and interactions in neuronal health and disease. Clinically, anti-PRPH antibodies are occasionally detected in autoimmune neurological disorders, though their pathogenic role remains unclear. Some studies associate them with neuropathies or paraneoplastic syndromes, but their diagnostic specificity is limited.
Notably, peripherin exists in multiple splice variants, and PRPH antibodies may exhibit varying reactivity depending on isoforms. This complicates interpretations in disease models. Recent work explores peripherin aggregation in ALS, with PRPH antibodies aiding in detecting pathological inclusions. Challenges include distinguishing between antibodies generated experimentally and those arising spontaneously in autoimmune conditions. Further research is needed to clarify their clinical relevance and potential as biomarkers or therapeutic targets.
成立日期 | 2024-06-24 (2年) | 注冊(cè)資本 | 50萬(wàn)(元) |
員工人數(shù) | 1-10人 | 年?duì)I業(yè)額 | ¥ 100萬(wàn)以內(nèi) |
主營(yíng)行業(yè) | 中間體,化學(xué)試劑 | 經(jīng)營(yíng)模式 | 貿(mào)易,工廠,試劑,定制,服務(wù) |
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