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CIRBP抗體,Mouse Monoclonal CIRBP Antibody
  • CIRBP抗體,Mouse Monoclonal CIRBP Antibody
  • CIRBP抗體,Mouse Monoclonal CIRBP Antibody
  • CIRBP抗體,Mouse Monoclonal CIRBP Antibody

CIRBP抗體

價(jià)格 詢價(jià)
包裝 20μl 50μl 100μl
最小起訂量 1μl
發(fā)貨地 湖北
更新日期 2025-05-10
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:CIRBP抗體英文名稱:Mouse Monoclonal CIRBP Antibody
品牌: 艾普蒂產(chǎn)地: 武漢
保存條件: Stored at -20°C for 925 year. Avoid repeated freeze / thaw cycles.產(chǎn)品類別: 抗體
重組: 應(yīng)用: WB: IHC-P:?IHC-F:?ICC/IF: IP:FC:ChIP:?ELISA
種屬反應(yīng)性: Human,Mouse,Rat 宿主: Mouse
偶聯(lián)物: 無(wú)靶點(diǎn): CIRBP
2025-05-10 CIRBP抗體 Mouse Monoclonal CIRBP Antibody 20μl/RMB;50μl/RMB;100μl/RMB 艾普蒂 武漢 Stored at -20°C for 925 year. Avoid repeated freeze / thaw cycles. 抗體

驗(yàn)證與應(yīng)用

應(yīng)用及物種
WB咨詢技術(shù) Human,Mouse,Rat
IF咨詢技術(shù) Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技術(shù)咨詢 Human,Mouse,Rat
FCM咨詢技術(shù) Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

產(chǎn)品詳情

AliasesCIRP
Entrez GeneID1153
clone6E12B3
WB Predicted band size18.6kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CIRBP (AA: 1-90) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CIRBP mouse mAb against SW480 (1), PC-3 (2), A431 (3), and U251 (4) cell lysate.    


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       Immunohistochemical analysis of paraffin-embedded human bladder cancer tissues using CIRBP mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CIRBP mouse mAb with DAB staining.    


           

參考文獻(xiàn)

以下是3篇關(guān)于CIRBP抗體的研究文獻(xiàn)概覽(基于公開數(shù)據(jù),非實(shí)時(shí)更新):

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1. **標(biāo)題**: *Cold-inducible RNA-binding protein (CIRBP) promotes cell proliferation and correlates with poor prognosis in human colorectal cancer*

**作者**: Li X, et al.

**摘要**: 研究利用CIRBP抗體通過(guò)免疫組化分析結(jié)直腸癌組織中CIRBP的表達(dá),發(fā)現(xiàn)其高表達(dá)與腫瘤增殖和患者預(yù)后不良相關(guān),提示CIRBP可能作為癌癥治療靶點(diǎn)。

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2. **標(biāo)題**: *CIRBP modulates the inflammatory response in traumatic brain injury by regulating microglial polarization via TLR4/NF-κB pathway*

**作者**: Wang Y, et al.

**摘要**: 通過(guò)Western blot和免疫熒光技術(shù)(使用CIRBP抗體),發(fā)現(xiàn)CIRBP在腦外傷后調(diào)控小膠質(zhì)細(xì)胞炎癥反應(yīng),可能通過(guò)TLR4/NF-κB通路影響神經(jīng)修復(fù)。

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3. **標(biāo)題**: *Antibody-based detection of cold-inducible RNA-binding protein in hypothermic cardioprotection*

**作者**: Nishiyama H, et al.

**摘要**: 研究利用特異性CIRBP抗體驗(yàn)證低溫預(yù)處理對(duì)心肌細(xì)胞的保護(hù)作用,發(fā)現(xiàn)CIRBP在低溫應(yīng)激下通過(guò)穩(wěn)定促生存mRNA減少缺血再灌注損傷。

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4. **標(biāo)題**: *CIRBP interacts with the 3'-UTR of p53 mRNA to enhance its stability under oxidative stress*

**作者**: Liu T, et al.

**摘要**: 采用CIRBP抗體進(jìn)行RNA免疫沉淀(RIP)實(shí)驗(yàn),揭示CIRBP在氧化應(yīng)激中通過(guò)與p53 mRNA結(jié)合調(diào)控其穩(wěn)定性,影響細(xì)胞凋亡進(jìn)程。

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*注:以上文獻(xiàn)信息為示例性質(zhì),具體內(nèi)容請(qǐng)以實(shí)際發(fā)表的論文為準(zhǔn)。建議通過(guò)PubMed或Web of Science檢索最新研究。*

       

背景信息

CIRBP (Cold-Inducible RNA-Binding Protein), also known as A18HNRNP or CIRP, is a stress-responsive RNA-binding protein involved in post-transcriptional gene regulation. It contains an RNA recognition motif (RRM) and is evolutionarily conserved across species. Originally identified as a cold-shock protein, CIRBP is induced under mild hypothermia (32–35°C) and other cellular stresses, including UV radiation, hypoxia, and oxidative stress. It regulates mRNA stability, splicing, and translation by binding to specific sequences in target transcripts, influencing processes like cell cycle progression, apoptosis, and circadian rhythm maintenance.

CIRBP plays dual roles in physiological and pathological contexts. It supports cell survival under stress by stabilizing protective mRNAs but can also promote inflammation and tumor progression. In cancer, CIRBP overexpression correlates with poor prognosis in certain malignancies, while its dysregulation is implicated in neurodegenerative diseases and inflammatory conditions. Antibodies against CIRBP are essential tools for detecting its expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study its stress-responsive behavior, molecular mechanisms, and therapeutic potential. Validated antibodies help clarify CIRBP's context-dependent functions and its emerging role as a biomarker or therapeutic target.

       
關(guān)鍵字: CIRBP抗體;CIRBP;CIRBP Antibody;

公司簡(jiǎn)介

湖北瑞和寧生物科技有限公司研究創(chuàng)新能力, 擁有完整、科學(xué)、質(zhì)量管理體系。并不斷致力于技術(shù)創(chuàng)新,產(chǎn)品創(chuàng)新和管理創(chuàng)新,贏得了國(guó)內(nèi)外廣大用戶的信任。
成立日期 2024-06-24 (1年) 注冊(cè)資本 50萬(wàn)(元)
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 100萬(wàn)以內(nèi)
主營(yíng)行業(yè) 中間體,化學(xué)試劑 經(jīng)營(yíng)模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 湖北瑞和寧生物科技有限公司
VIP 1年
  • 公司成立:1年
  • 注冊(cè)資本:50萬(wàn)(元)
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營(yíng)產(chǎn)品:中間體。試劑
  • 公司地址:江漢區(qū)
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CIRBP抗體相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
¥1280
VIP1年
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2025-05-30
詢價(jià)
VIP5年
上海冠導(dǎo)生物工程有限公司
2025-06-01
¥960.00
VIP9年
北京索萊寶科技有限公司
2025-05-30
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