反苯環(huán)丙胺鹽酸鹽,Tranylcypromine (2-PCPA) hydrochloride

反苯環(huán)丙胺鹽酸鹽|T1025|TargetMol

價(jià)格	￥258	￥413	￥543
包裝	50mg	100mg	200mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2025-03-12

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產(chǎn)品詳情

中文名稱:反苯環(huán)丙胺鹽酸鹽	英文名稱:Tranylcypromine (2-PCPA) hydrochloride
CAS:1986-47-6	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: store under nitrogen,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.86%	產(chǎn)品類別: 抑制劑
貨號(hào): T1025

Product Introduction

Bioactivity

名稱	Tranylcypromine (2-PCPA) hydrochloride
描述	Tranylcypromine (2-PCPA) hydrochloride (SKF-385 HCl), a Monoamine Oxidase inhibitor, is effective in the treatment of major depression, dysthymic disorder, and atypical depression.
激酶實(shí)驗(yàn)	PDE activity is determined with some modifications. The assay mixture contain 50 mM Tris (pH 7.4), 5 mM MgCl2, 0.5 μM cAMP or cGMP, and [3H]cAMP or [3H]cGMP (about 30,000 cpm/assay), the indicated concentration of the inhibitor and an aliquot of the enzyme solution at a final assay volume of 200 μL. Stock solutions of the compounds are diluted 1:100 (v/v) in the Tris buffer mentioned above; appropriate dilutions are prepared in 1% (v/v) DMSO/Tris buffer, which are diluted 1:2 (v/v) in the assays to obtain the desired final concentrations of the inhibitors at a DMSO concentration of 0.5% (v/v). DMSO itself affected none of the PDE activities. After preincubation for 5 min at 37°C, the reaction is started by the addition of substrate (cAMP or cGMP) and the assays are incubated for further 15 min at 37°C. Then 50 μL of 0.2 N HCl is added to stop the reaction and the assays are left on ice for about 10 min. Following incubation with 25 μg of 5′-nucleotidase (Crotalus atrox snake venom) for 10 min at 37°C, the assays are loaded on QAE Sephadex A-25 (1 mL of bed volume in Poly-Prep chromatography columns). The columns are eluted with 2 mL of 30 mM ammonium formate (pH 6.0) and the eluate is counted for radioactivity. Results are corrected for blank values (measured in the presence of denatured protein) that are below 5% of total radioactivity. The amount of cyclic nucleotides hydrolyzed did not exceed 30% of the original substrate concentration[3].
體外活性	與空白對(duì)照組相比,Tranylcypromine（5 mg/kg和10 mg/kg）可大而緩的增加雄性大鼠的肌肉活動(dòng),但2 mg/kg的Tranylcypromine沒(méi)有效果. Tranylcypromine（10 mg/kg）使雄性大鼠飼養(yǎng)行為數(shù)量顯著增加.
體內(nèi)活性	在小牛主動(dòng)脈內(nèi)皮細(xì)胞中,Tranylcypromine（500 μg/mL）可強(qiáng)烈抑制緩激肽誘導(dǎo)的花生四烯酸釋放。 Tranylcypromine還能抑制HLMs中的CYP2A6（IC50：0.42 μM）和CYP2E1（IC50：3 μM）活性。在HLMs中,Tranylcypromine引起II型和環(huán)丙基苯I型的差異譜。HLMs中CYP2A6介導(dǎo)的尼古丁代謝可被R-(+)-Tranylcypromine（Ki：0.05 μM）,(±)-Tranylcypromine（Ki：0.08 μM）以及S-(-)-Tranylcypromine（Ki：2.0 μM）完全抑制。
存儲(chǔ)條件	store under nitrogen,store at low temperature \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	H2O : 17 mg/mL (100.2 mM), Sonication is recommended. DMSO : 65 mg/mL (383.12 mM), Sonication is recommended.
關(guān)鍵字	Tranylcypromine (2-PCPA) Hydrochloride \| Tranylcypromine (2PCPA) hydrochloride \| Tranylcypromine (2 PCPA) hydrochloride \| MAO \| LSD1 \| HistoneDemethylase \| Histone Demethylase
相關(guān)產(chǎn)品	Safinamide \| Hydralazine hydrochloride \| Procaine \| Hydroxyamine hydrochloride \| Procaine hydrochloride \| Isatin \| Eicosapentaenoic Acid \| Daminozide \| Allylthiourea \| Paeonol \| Azure B \| Furazolidone
相關(guān)庫(kù)	抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌上市藥物庫(kù) \| 抗癌活性化合物庫(kù) \| 已知活性化合物庫(kù) \| 臨床失敗化合物庫(kù) \| 抗衰老化合物庫(kù) \| 高選擇性抑制劑庫(kù) \| FDA 上市藥物庫(kù) \| 神經(jīng)退行性疾病化合物庫(kù) \| 藥物功能重定位化合物庫(kù) \| 抗癌藥物庫(kù)

關(guān)鍵字：反苯環(huán)丙胺鹽酸鹽|||Tranylcypromine (2-PCPA) HCl|||SKF-385 HCl|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （13年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

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公司成立：13年
注冊(cè)資本：566.2651萬(wàn)人民幣
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