Human gp130 / CD130 / IL-6 R beta Protein, His Tag (MALS verified)
表達區(qū)間及表達系統（Source）
Human gp130, His Tag (ILT-H52H2) is expressed from human 293 cells (HEK293). It contains AA Glu 23 - Glu 619 (Accession # P40189-1).
Predicted N-terminus: Glu 23
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 69.6 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
白細胞介素-6受體亞基β（IL6ST）也稱為IL-6受體亞基α、IL-6R亞基β、IL-6Rβ、IL-6RB、白細胞介蛋白-6信號轉導子、膜糖蛋白130（gp130）、CD130、Oncostatin-M受體亞基a和IL6ST，后者是單程I型膜蛋白。IL6ST/gp130/CD130可以在腦、心臟、胸腺、脾臟、腎臟、肺和肝臟等組織中發(fā)現，并且在除BaF-B03之外的所有測試細胞系中都有發(fā)現。IL-6ST/gp130的表達不限于IL6反應細胞。IL6、LIF、OSM、CNTF、IL11、CTF1和BSF3的受體系統可以利用gp130啟動信號傳輸。IL6ST/CD130可以與IL6/IL6R（α鏈）復合物結合，形成高親和力IL6結合位點，并轉導信號。IL6ST/GP130不結合IL6，可能在胚胎發(fā)育中發(fā)揮作用。
關鍵字： gp130;gp130蛋白;gp130重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。