中文名：壬二酸
英文名：Azelaic acid
中文別名：杜鵑花酸|1,7-庚二甲酸
英文別名：azelaic acid|NONANEDIOIC ACID|123-99-9|Finacea|Anchoic acid|Azelex|Lepargylic acid|1,7-Heptanedicarboxylic acid|Skinoren|1,9-Nonanedioic acid|Heptanedicarboxylic acid|n-Nonanedioic acid|Emerox 1110|Emerox 1144|azelate|acide azelaique|acidum azelaicum|Fine
純度：10mM in DMSO
貨號：A421035
包裝：1ml
Cas號：123-99-9
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Azelaic acid is a dicarboxylic acid that exhibits anti-inflammatory activity. It is known for it’s anti acne activity in vitro. Azelaic acid directly inhibits kallikrein 5 (KLK5), downregulating expression of KLK5, toll-like receptor 2 (TLR 2), and cathelicidin, and suppresses activity of serine proteases in vitro, in vivo, and in clinical settings. In PUFA-treated fibroblasts, azelaic acid decreases generation of ROS and upregulates expression of antioxidative enzymes, inhibiting cell damage; agonist activity at PPARν is thought to drive these effects. Azelaic acid also inhibits proliferation of melanocytes. This compound displays antiacne and anticancer potential as well, inhibiting the proliferation of cutaneous melanoma due to suppression of mitochondrial oxidoreductive activity and DNA synthesis.
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關(guān)鍵字： 杜鵑花酸;1,7-庚二甲酸;azelaic acid;NONANEDIOIC ACID
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