Product Name：[Des-His1，Glu9]-Glucagon (1-29), amide
CAS No.：110084-95-2
Synonyms：胰高血糖素受體拮抗劑多肽
Catalog No.：153P20
Brand：HongTide（上海鴻肽生物）
Description：[Des-His1，Glu9]-Glucagon (1-29), amide是胰高血糖素受體拮抗劑多肽，序列中N端個His取消，第9個氨基酸Asp換成Glu，并且C端酰胺化。用于抑制大鼠肝膜中胰高血糖素誘導的腺苷酸環(huán)化酶活化，不顯示激動劑活性。 在體外增強葡萄糖刺激的胰腺胰島素釋放。 在正常兔中阻斷胰高血糖素誘導的高血糖癥，而不影響體內糖原分解。 還可阻斷鏈脲佐菌素糖尿病大鼠的內源性胰高血糖素誘導的高血糖癥。
[Des His1, Glu9] - Glucagon (1-29), amide is a glucagon receptor antagonist peptide, with the first His at the N-terminus cancelled, the 9th amino acid Asp replaced with Glu, and the C-terminus amidated. Used to inhibit the activation of adenylate cyclase induced by glucagon in the liver membrane of rats, without showing agonist activity. Enhanced glucose stimulated pancreatic insulin release in vitro. Blocking glucagon induced hyperglycemia in normal rabbits without affecting glycogen breakdown in the body. It can also block the endogenous glucagon induced hyperglycemia in streptozotocin diabetes rats.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | SQGTFTSEYSKYLDSRRAQDFVQWLMNT-NH2 |
Sequence(3-letter code) | H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Glu-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Val-Gln-Trp-Leu-Met-Asn-Thr-NH2 |
Peptide Structure | ![[Des-His1，Glu9]-Glucagon (1-29), amide 110084-95-2.png](/SupplyImg/2023-08-23/6382840149384143667602579.jpg "[Des-His1，Glu9]-Glucagon (1-29), amide 110084-95-2.png")
|
Molecular Formula | C148H221N41O47S |
Molecular Weight | 3358.72 |
訂購聯(lián)系方式：
上海鴻肽生物科技有限公司
手機： +86-18018095145 （同微信號）
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郵箱：sales1@hongtide.com
關鍵字： [Des-His1，Glu9]-Gluc;110084-95-2;胰高血糖素受體拮抗劑多肽;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡稱：鴻肽生物）是一家以多肽以及多肽上下游產品研發(fā)、生產、銷售以及技術轉讓為主要業(yè) 務科技公司。公司現有產品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來，秉持“用質量作船， 以服務為帆，為科研服務”的企業(yè)理念，為國內外眾多科研工作者提供了優(yōu)質的服務及產品。