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Citicoline
別名: CDP-choline, cytidine 5'-diphosphocholine 中文名稱：腦二磷膽堿
Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis.
Citicoline Chemical Structure
CAS: 987-78-0
產(chǎn)品質(zhì)控
批次：
S536201
Water]97 mg/mL]false]DMSO]Insoluble]false]]]false
純度：
99.96%
99.96
Citicoline相關產(chǎn)品
生物活性
| 產(chǎn)品描述 | Citicoline (CDP-choline, cytidine 5'-diphosphocholine) is a naturally occurring compound that acts as nutrient with a broad spectrum of benefits for conditions associated with symptoms of neurological dysfunction. As an endogenous compound, it is also an essential intermediate in the synthesis of cell membrane phospholipids and its formation is the rate-limiting step in phosphatidylcholine synthesis. |
|---|
| NCT Number | Recruitment | Conditions | Sponsor/Collaborators | Start Date | Phases |
|---|---|---|---|---|---|
| NCT05881135 | Recruiting | COVID-19 |
Ohio State University |
June 6 2023 | Phase 1|Phase 2 |
| NCT05200208 | Recruiting | Alzheimer Disease |
Emory University|National Institute on Aging (NIA)|Goizueta Alzheimer''s Disease Research Center (ADRC) |
July 27 2022 | Not Applicable |
| NCT05315206 | Recruiting | Primary Open Angle Glaucoma |
Fondazione G.B. Bietti IRCCS |
January 25 2022 | Not Applicable |
| NCT05000190 | Completed | Attention |
PepsiCo Global R&D |
September 13 2021 | Not Applicable |
| NCT05154903 | Unknown status | Acute Ischemic Stroke |
Ain Shams University|Kafrelsheikh University |
July 22 2021 | Phase 3 |
| NCT04003090 | Completed | Neurodegenerative Diseases |
Istituto di Ricerca Neuroftalmologia S.r.l.|Fondazione G.B. Bietti IRCCS |
March 21 2018 | Not Applicable |
化學信息&溶解度
| 分子量 | 488.32 | 分子式 | C14H26N4O11P2 |
| CAS號 | 987-78-0 | SDF | -- |
| Smiles | C[N+](C)(C)CCOP(=O)([O-])OP(=O)(O)OCC1C(C(C(O1)N2C=CC(=NC2=O)N)O)O | ||
| 儲存條件(自收到貨起) | 3年 -20°C 粉狀 | ||
|
體外溶解度 |
Water : 97 mg/mL (198.64 mM) DMSO : Insoluble ( ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO) |
摩爾濃度計算器 |
|
體內(nèi)溶解度 現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑 |
動物體內(nèi)配方計算器 | ||||
實驗計算
動物體內(nèi)配方計算器（澄清溶液）
第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）
mg/kg
g
μL
只
第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）
% DMSO
%
% Tween 80
% ddH2O
%DMSO
%
計算結(jié)果：
工作液濃度： mg/ml；
DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；
體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH2O，混勻澄清。
體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。
注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。
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