Cidofovir

別名: HPMPC, GS 0504 中文名稱：西多福韋

目錄號：S1516 Purity: 99.89%

Cidofovir通過選擇性抑制病毒DNA的合成而抑制病毒復(fù)制。

Cidofovir Chemical Structure

CAS: 113852-37-2

規(guī)格	價格	庫存
25mg	811.35	現(xiàn)貨
100mg	2198.16	現(xiàn)貨
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產(chǎn)品質(zhì)控

批次：純度： 99.89%

99.89

Cidofovir相關(guān)產(chǎn)品

相關(guān)靶點	tRNA synthetase RdRp DNA synthesis helicase ribonucleotide reductase	點擊展開
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相關(guān)化合物庫	FDA藥物庫天然產(chǎn)物庫凋亡分子化合物庫 DNA損傷/ DNA修復(fù)化合物庫細胞周期化合物庫	點擊展開

細胞實驗數(shù)據(jù)示例

細胞系	實驗類型	孵育時間	活性描述	文獻信息
HEL cells	Function assay	3 days	Antiviral activity against HCMV AD169 infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=0.41 μM	17961851
HEL cells	Function assay	3 days	Antiviral activity against HCMV Davis infected in HEL cells assessed as reduction of virus-induced cytopathogenicity after 3 days, EC50=0.41 μM	17961851
HFF	Proliferation assay	3 days	Antiproliferative activity against HFF after 3 days by coulter counter assay, EC50=1.9 μM	19029322
HeLaS3 cells	Function assay	3-5 days	Antiviral activity against Vaccinia virus IHD-J ATCC VR-156 infected in HeLaS3 cells after 3 to 5 days by plaque assay, EC50=18.74 μM	18852271
HSB2 cells	Function assay	7 days	Antiviral activity against Human herpesvirus 6 GS infected in human HSB2 cells assessed as decrease in viral DNA accumulation after 7 days, EC50=2.7 μM	19770274
HEL cells	Function assay		Compound was tested for anti-viral activity against HSV-1(KOS) in HEL cells, EC50=0.57 μM	14643328
MRC-5 cells	Function assay		Inhibitory activity against cytopathic effect of HSV-2(E 194) in MRC-5 cells, IC50=10 μM	8632439
NHDF cells	Function assay		Inhibitory activity against replication of HCMV in NHDF cells, IC50=0.5 μM	8632439
HFF cells	Function assay		Antiviral activity against Vaccinia virus Copenhagen in HFF cells assessed as reduction in cytopathogenicity, EC50=3.2 μM	16603351
HFF cells	Function assay		Antiviral activity against Cowpox virus Brighton in HFF cells assessed as reduction in cytopathogenicity, EC50=7.1 μM	16603351
HFF cells	Function assay		Antiviral activity against vaccinia virus Copenhagen measured as cytopathogenicity in HFF cells, EC50=6.9 μM	16722657
bone marrow cells	Cytotoxicity assay		Cytotoxicity against human bone marrow cells assessed as inhibition of colony forming unit of granulocyte/macrophage, IC50=10 μM	16814545
HFF cells	Function assay		Antiviral activity against Human CMV T2241 in HFF cells by SEAP assay, IC50=0.3 μM	17043128
MRC5 cells	Function assay		Antiviral activity against Human CMV Towne in MRC5 cells by PRA, IC50=0.3 μM	17043128
UC1B cells	Function assay		Antiviral activity against Murine polyomavirus MN/RDE Toronto in mouse UC1B cells assessed as reduction of virus-induced cytopathogenicity, EC50=13 μM	17420214
african green monkey Vero cells	Function assay		Antiviral activity against Herpes simplex virus 1 F infected in african green monkey Vero cells assessed as plaque reduction after 36 to 48 hrs, EC50=14.4 μM	17438061
HFF cells	Function assay		Antiviral activity against Cytomegalovirus CMV T2211 infected in HFF cells by SEAP reporter gene assay, EC50=0.22 μM	17709468
HEL cells	Function assay		Antiviral activity against ganciclovir-resistant HCMV AD169 clone 4 infected in HEL cells assessed as inhibition of virus-induced cytopathicity, EC50=0.74 μM	19226140
HEL cells	Function assay		Antiviral activity against HCMV Davis infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=0.5 μM	19226140
HEL cells	Function assay		Antiviral activity against HCMV AD169 infected in human HEL cells assessed inhibition of virus-induced cytopathicity after 7 days postinfection, EC50=0.3 μM	19226140
HEL cells	Function assay		Antiviral activity against foscarnet-resistant HCMV AD169 clone C infected in HEL cells assessed as inhibition of virus-induced cytopathicity, IC50=0.045 μM	19226140
A549 cells	Function assay		Antiviral activity against Human adenovirus type 11p slobitski infected in A549 cells assessed as inhibition of DNA replication by QPCR assay, EC50=16.5 μM	20585112
HFF cells	Function assay		Antiviral activity against Cowpox virus (Brighton Red) infected in human HFF cells assessed as reduction in viral-induced cytopathic effect by neutral red uptake assay, EC50=6.7 μM	21376429
點擊查看更多細胞系數(shù)據(jù)

生物活性

產(chǎn)品描述	Cidofovir通過選擇性抑制病毒DNA的合成而抑制病毒復(fù)制。

體外研究(In Vitro)
體外研究活性	Cidofovir處理培養(yǎng)的細胞，抑制人類巨細胞病毒（HCMV）感染。Cidofovir抑制巨細胞病毒（CMV）蝕斑形成，即使是感染后48小時后加入到細胞中，作用于Davis和AD-169株時IC50分別為0.9 μg/mL和1.6 μg/mL。^[1] Cidofovir也抑制單純皰疹病毒感染。此外，Cidofovir作用于猴腎細胞，抑制HSV-1誘導(dǎo)的細胞融合，也抑制HSV-1特異性蛋白的表達和病毒DNA的合成。^[3]

體內(nèi)研究(In Vivo)
體內(nèi)研究活性	Cidofovir 每天按5 mg/kg劑量皮下注射給藥受感染的豚鼠，持續(xù)給藥5天，顯著降低血，脾，肺，和唾液腺中病毒傳染力。Cidofovir處理受感染的動物，顯著降低淋巴細胞增多和脾臟的平均組織指數(shù)。^[2] Cidofovir作用于皮內(nèi)感染與HSV-1或HSV-2的無毛小鼠，抑制所有臨床表現(xiàn)（皮膚損傷，后腿癱瘓，和死亡）。Cidofovir最顯著的特點是感染后到直至第4天才單獨給藥，也顯著抗HSV-1或HSV-2感染。^[4] Cidofovir作用于皮下移植小鼠黑色素瘤B16細胞的C57B16/J小鼠，抑制產(chǎn)生的高度侵襲性的黑色素瘤的生長。^[5]

NCT Number	Recruitment	Conditions	Sponsor/Collaborators	Start Date	Phases
臨床試驗信息 (data from https://clinicaltrials.gov, updated on 2024-05-22)
NCT04542252	Completed	Drug Drug Interaction	SymBio Pharmaceuticals	November 9 2020	Phase 1
NCT01610765	Withdrawn	Herpes Simplex Virus	University of Alabama at Birmingham	January 2016	Phase 1\|Phase 2
NCT01816646	Completed	Blood And Marrow Transplantation	M.D. Anderson Cancer Center\|Gilead Sciences	September 2013	Phase 1
NCT00780182	Completed	Healthy	Chimerix\|National Institutes of Health (NIH)	October 2008	Phase 1

參考文獻
[1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844. [2] Li SB, et al. Antiviral Res, 1990, 13(5), 237-252. [3] Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192. [4] De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706. [5] Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748. + 展開

參考文獻

[1] Snoeck R, et al, Antimicrob Agents Chemother, 1988, 32(12), 1839-1844.
[2] Li SB, et al. Antiviral Res, 1990, 13(5), 237-252.
[3] Chatterjee S, et al. Antiviral Res., 1992, 19(3), 181-192.

[4] De Clercq E, et al. Antimicrob Agents Chemother, 1991, 35(4), 701-706.
[5] Redondo P, et al. Br J Dermatol, 2000, 143(4), 741-748.

+ 展開

化學信息&溶解度

分子量	279.19	分子式	C₈H₁₄N₃O₆P
CAS號	113852-37-2	SDF	Download Cidofovir SDF
Smiles	C1=CN(C(=O)N=C1N)CC(CO)OCP(=O)(O)O
儲存條件(自收到貨起)	3年-20°C粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1年-80°C溶于溶劑
儲存條件(自收到貨起)	3年-20°C粉狀	儲備液保存和期限建議分裝儲備液，避免反復(fù)凍融！	1個月-20°C溶于溶劑

體外溶解度
批次：

Water : 5 mg/mL (17.9 mM)

DMSO : Insoluble ( ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : Insoluble

Water : 7 mg/mL (25.07 mM)

DMSO : Insoluble ( ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : Insoluble

Water : 12 mg/mL (42.98 mM)

DMSO : 2 mg/mL ( (7.16 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : Insoluble

Water : 7 mg/mL (25.07 mM)

DMSO : 0.005 mg/mL ( (0.01 mM) ；DMSO吸濕會降低化合物溶解度，請使用新開封DMSO)

Ethanol : Insoluble

摩爾濃度計算器

體內(nèi)溶解度
批次：

現(xiàn)配現(xiàn)用，請按從左到右的順序依次添加，澄清后再加入下一溶劑

動物體內(nèi)配方計算器

實驗計算

摩爾濃度計算器

質(zhì)量	濃度	體積	分子量
=	×	×

稀釋計算器分子量計算器

動物體內(nèi)配方計算器（澄清溶液）

第一步：請輸入基本實驗信息（考慮到實驗過程中的損耗，建議多配一只動物的藥量）

給藥劑量 mg/kg 動物平均體重 g 每只動物給藥體積 μL 動物數(shù)量只

第二步：請輸入動物體內(nèi)配方組成（配方適用于不溶于水的藥物；不同批次藥物配方比例不同，請聯(lián)系Selleck為您提供正確的澄清溶液配方）

% DMSO + % + % Tween 80 + % ddH2O

%DMSO+ %

計算結(jié)果：

工作液濃度： mg/ml；

DMSO母液配制方法： mg 藥物溶于μL DMSO溶液（母液濃度mg/mL，注：如該濃度超過該批次藥物DMSO溶解度，請先聯(lián)系Selleck）；

體內(nèi)配方配制方法：取μL DMSO母液，加入μL PEG300，混勻澄清后加入μL Tween 80，混勻澄清后加入μL ddH₂O，混勻澄清。

體內(nèi)配方配制方法：取μL DMSO母液，加入μL Corn oil，混勻澄清。

注意：1. 首先保證母液是澄清的；
2.一定要按照順序依次將溶劑加入，進行下一步操作之前必須保證上一步操作得到的是澄清的溶液，可采用渦旋、超聲或水浴加熱等物理方法助溶。

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Cidofovir

產(chǎn)品質(zhì)控

Cidofovir相關(guān)產(chǎn)品

相關(guān)信號通路圖

細胞實驗數(shù)據(jù)示例

生物活性

化學信息&溶解度

實驗計算

技術(shù)支持