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  2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Sepiapterin

L-Sepiapterin (Sepiapterin) 是內(nèi)皮型一氧化氮合酶 (eNOS) 輔因子四氫生物喋呤 (BH4) 的前體。L-Sepiapterin 改善 db/db 小鼠腸系膜小動脈內(nèi)皮功能障礙，誘導(dǎo)血管生成。L-Sepiapterin 通過下調(diào) p70S6K 依賴性 VEGFR-2 表達(dá)抑制卵巢癌細(xì)胞增殖和遷移。

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L-Sepiapterin Chemical Structure

L-Sepiapterin Chemical Structure

CAS No. : 17094-01-8

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規(guī)格 價格 是否有貨 數(shù)量
1 mg ￥15840
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Customer Review

  • 生物活性

  • 純度 & 產(chǎn)品資料

  • 參考文獻(xiàn)

生物活性

L-Sepiapterin (Sepiapterin) is a precursor of the endothelial nitric oxide synthase (eNOS) cofactor tetrahydrobiopterin (BH4). L-Sepiapterin improves endothelial dysfunction in small mesenteric arteries from db/db mice, and induces angiogenesis. L-Sepiapterin inhibits cell proliferation and migration of ovarian cancer cells via down-regulation of p70S6K-dependent VEGFR-2 expression[1][2].

IC50 & Target[1]

Human Endogenous Metabolite

 

體外研究
(In Vitro)

L-Sepiapterin (Sepiapterin) (0.1-10 μM；24 小時) 以劑量依賴性方式誘導(dǎo)細(xì)胞增殖[1]。
L-Sepiapterin (1-50 μM；20 分鐘) 顯著抑制 VEGF-A 誘導(dǎo)的 (50 ng/mL) p70S6K[1] 的磷酸化。
L-Sepiapterin 抑制 VEGF-A 誘導(dǎo)的磷酸化細(xì)胞增殖和遷移通過 NO 獨(dú)立機(jī)制[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: SKOV-3 cells
Concentration: 0.1, 1, 10 μM
Incubation Time: 24 hours
Result: Induced cell proliferation in a dose-dependent manner.
體內(nèi)研究
(In Vivo)

L-Sepiapterin (Sepiapterin) (10 mg/kg；po (粉末食物)；每日一次，持續(xù)或 8 周) 顯著改善 db/db 小鼠腸系膜小動脈 (SMA) 中 Ach 的松弛[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/KsJ diabetic mice (db/db)[2]
Dosage: 10 mg/kg
Administration: P.o. (powder chow); daily for or 8 weeks
Result: Significantly improved the relaxation to Ach in SMA from db/db mice.
Clinical Trial
分子量

237.22

Formula

C9H11N5O3
CAS 號
性狀

固體

顏色

White to yellow

結(jié)構(gòu)分類
初始來源
運(yùn)輸條件

Room temperature in continental US; may vary elsewhere.
儲存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
純度 & 產(chǎn)品資料

純度: ≥95.0%

參考文獻(xiàn)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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產(chǎn)品名稱：
L-Sepiapterin
目錄號：
HY-112234
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