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xl647

  Cat. No.:  DC3129  
Chemical Structure
781613-23-8
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More than 5000 active chemicals with high quality for research!
Field of application
XL647 is a novel spectrum-selective kinase inhibitor for EGFR, ErbB2, KDR, Flt-4 and EphB4 with IC50 of 0.3 nM, 16 nM, 1.5 nM, 8.7 nM and 1.4 nM, respectively.
Cas No.: 781613-23-8
Chemical Name: N-(3,4-dichloro-2-fluorophenyl)-6-methoxy-7-(((3aR,5r,6aS)-2-methyl-octahydrocyclopenta[c]pyrrol-5-yl)methoxy)quinazolin-4-amine
Synonyms: EXEL-7647,xl-647,xl 647
SMILES: [H][C@@]12[C@@](C[C@@H](COC3=CC4=C(C(NC5=C(F)C(Cl)=C(Cl)C=C5)=NC=N4)C=C3OC)C2)([H])CN(C)C1
Formula: C24H25Cl2FN4O2
M.Wt: 491.39
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: For the detailed information about the solubility of xl-647 in water, the solubility of xl-647 in DMSO, the solubility of xl-647 in PBS buffer, the animal experiment（test） of xl-647,the in vivo,in vitro and clinical trial test of xl-647,the cell experiment（test） of xl-647,the IC50, EC50 and Affinity of xl-647, please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
Cat. No. Product name Field of application
DC3129 xl647 XL647 is a novel spectrum-selective kinase inhibitor for EGFR, ErbB2, KDR, Flt-4 and EphB4 with IC50 of 0.3 nM, 16 nM, 1.5 nM, 8.7 nM and 1.4 nM, respectively.
DC11722 PF-06459988 PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
DC11721 PF-06747775 A potent, selective, irreversible EGFR mutants with IC50 of 12, 3, 4 and 5 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively.
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