80-fold selectivity over group I and group III receptors." />

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LY 379268

  Cat. No.:  DC7148   Featured
Chemical Structure
191471-52-0
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More than 5000 active chemicals with high quality for research!
Field of application
Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM for hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors.
Cas No.: 191471-52-0
Chemical Name: LY 379268
Synonyms: LY 379268;(1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid;CHEBI:104347;CHEMBL275079;CTK8F0567;DNC007065;LS-98795;LY-379268;SureCN2454646;LY397268;(1R,4R,5S,6R)-4-Amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid;2-Oxabicyclo[3.1.0]hexane-4,6-dicarboxylicacid,4-amino-,(1R,4R,5S,6R)-
SMILES: O=C([C@@]1(N)[C@]2([H])[C@@H](C(O)=O)[C@]2([H])OC1)O
Formula: C7H9NO5
M.Wt: 187.15006
Purity: >98%
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: Highly selective group II mGlu receptor agonist (EC50 values are 2.69 and 4.48 nM For hmGlu2 and hmGlu3 respectively) that displays > 80-fold selectivity over group I and group III receptors. Provides protection against NMDA-mediated cell death in vitro and offers almost complete protection against CA1 hippocampal damage following global ischemia in gerbils. Orally and systemically active. For the detailed information of LY379268, the solubility of LY379268 in water, the solubility of LY379268 in DMSO, the solubility of LY379268 in PBS buffer, the animal experiment (test) of LY379268, the cell expriment (test) of LY379268, the in vivo, in vitro and clinical trial test of LY379268, the EC50, IC50,and Affinity of LY379268, Please contact DC Chemicals.
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
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