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PF-1355

  Cat. No.:  DC25200   Featured
Chemical Structure
1435467-38-1
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More than 5000 active chemicals with high quality for research!
Field of application
PF-1355 is a potent, selective, orally active Myeloperoxidase (MPO) inhibitor with EC50 of 1.47 uM.
Cas No.: 1435467-38-1
Chemical Name: 1(2H)-Pyrimidineacetamide, 6-(2,5-dimethoxyphenyl)-3,4-dihydro-4-oxo-2-thioxo-
Synonyms: PF06281355;PF1355;PF 1355;PF-06281355;PF 06281355
SMILES: O=C(CN1C(=CC(=O)NC1=S)C1C(OC)=CC=C(OC)C=1)N
Formula: C14H15N3O4S
M.Wt: 321.3516
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases.
In Vivo: Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Goodpasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment[1].
In Vitro: In a dose-responsive fashion, PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM)[1].
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
2018-0101
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