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YH239-EE

  Cat. No.:  DC9504   Featured
Chemical Structure
1364488-67-4
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More than 5000 active chemicals with high quality for research!
Field of application
YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent
Cas No.: 1364488-67-4
Chemical Name: YH 239-EE;YH 239 EE
Synonyms: YH 239-EE;YH 239 EE
SMILES: O=C(C(N1)=C(C(N(CC2=CC=C(Cl)C=C2)C=O)C(NC(C)(C)C)=O)C3=C1C=C(Cl)C=C3)OCC
Formula: C25H27Cl2N3O4
M.Wt: 504.4056
Sotrage: 2 years -20°C Powder, 2 weeks 4°C in DMSO, 6 months -80°C in DMSO
Description: YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC10851 PK11000 PK11000 is an alkylating agent, and stabilizes the DNA-binding domain of both WT and mutant p53 by covalent cysteine modification, without compromising DNA binding.
DC9504 YH239-EE YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent
DC7314 Tenovin-3 Tenovin-3 is a small molecule activator of p53 transcriptional activity.
DC8467 RO8994 RO8994 is a potent and selective spiroindolinone MDM2 inhibitor for cancer therapy.
DC8865 RG-7112 RG7112 (RO5045337) is an orally bioavailable and selective p53-MDM2 inhibitor.
DC10070 PRIMA-1MET(APR-246) PRIMA-1MET is methylated derivative of PRIMA-1. It can restore mutant p53 activity.
DC9902 PRIMA-1 PRIMA-1 is a mutant p53 reactivator, restores the sensitivity of TP53 mutant-type thyroid cancer cells to the histone methylation inhibitor 3-Deazaneplanocin A.
DC9257 NSC59984 NSC59984 induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway.The EC50 of NSC59984 in most cancer cells is significantly lower than those of normal cells, with EC50 of 8.38 μM for p53-null HCT116 cells.
DC10074 MX69 MX69 is the MDM2/XIAP inhibitor, used for cancer treatment.
DC8414 MI-77301 (SAR405838) MI-77301 (SAR405838) is an orally available MDM2 antagonist with Ki of 0.88 nM. Phase 1.
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