6-[[(4R,5S,6S)-2-Carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]thio]-6,7-dihydro-5H-pyrazolo[1,2-a][1,2,4]triazol-4-ium inner salt
IDENTITY
CAS Number:
120410-24-4
MDL Number:
MFCD00864863
MF:
C15H18N4O4S
MW:
350.39
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
235-242°C
Optical Rotation:
-32.9° (c=5)
Long-Term Storage:
Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
DMSO: <1mg/mL; H2O: 16mg/mL; EtOH: <1mg/mL
Application(s):
Antibiotic
Form:
Free Base
REVIEW A carbapenem antibiotic. It has in vitro activity against anaerobes. REFERENCES
[1]
Ikawa K, Nakashima A, Morikawa N, Ikeda K, Murakami Y, Ohge H, Derendorf H, Sueda T (2011). Clinical pharmacokinetics of meropenem and biapenem in bile and dosing considerations for biliary tract infections based on site-specific pharmacodynamic target attainment. Antimicrob Agents Chemother. 55(12):5609-15. PMID 21947393.
[2]
Gatti DL (2012). Biapenem inactivation by B2 metallo β-lactamases: energy landscape of the post-hydrolysis reactions. PLoS One. 7(1):e30079. PMID 22272276.
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