AMP-activated protein kinase (AMPK); Epatic gluconeogenesis inhibitor
Form:
HCl salt
REVIEW An antidiabetic drug in the biguanide class. Metformin activates AMP-activated protein kinase (AMPK), an enzyme that plays an important role in insulin signaling, whole body energy balance, and the metabolism of glucose and fats. Activation of AMPK is required for metformin''s inhibitory effect on the production of glucose by liver cells.
REFERENCES
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Witters LA: The blooming of the French lilac. J Clin Invest. 2001 Oct;108(8):1105-7.
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UNGAR G, FREEDMAN L, SHAPIRO SL: Pharmacological studies of a new oral hypoglycemic drug. Proc Soc Exp Biol Med. 1957 May;95(1):190-2.
[3]
Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ. 2003 Oct 25;327(7421):951-3.
[4]
Marchesini G, Brizi M, Bianchi G, Tomassetti S, Zoli M, Melchionda N: Metformin in non-alcoholic steatohepatitis. Lancet. 2001 Sep 15;358(9285):893-4.
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