Venlafaxine hydrochloride NEW
| Price | $32 | $50 | $72 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Venlafaxine hydrochloride | CAS No.: 99300-78-4 |
| Purity: 99.69% | Supply Ability: 10g |
| Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Venlafaxine hydrochloride |
| Description | Venlafaxine hydrochloride (Wy 45030 hydrochloride) is a cyclohexanol and phenylethylamine derivative functioning as a serotonin and noradrenaline reuptake inhibitor (SNRI) used as an antidepressive agent. |
| In vitro | In mice, the analgesic effect induced by Venlafaxine is significantly inhibited by naloxone, nor-BNI, and naltrexone indol, indicating involvement of kappa (κ-) and delta (δ-) opioid mechanisms, but not by β-FNA or naloxazone. In fully developed neuropathic rats, Venlafaxine reverses hyperalgesia. Venlafaxine demonstrates a dose-dependent analgesic effect with an ED50 of 46.7 mg/kg in mice. |
| In vivo | Venlafaxine exhibits lower potential for inhibiting the metabolism of CYP2D6 substrates compared to widely used SSRIs such as desipramine and imipramine and can also inhibit the metabolism of several other major human hepatic P450 substrate enzymes. It inhibits the binding to human noradrenaline and serotonin transporters with K(i) values of 2480 nM and 82 nM, respectively. Furthermore, venlafaxine blocks p-chloroamphetamine and 6-hydroxydopamine-induced monoamine depletion with ED(50) values of 5.9 mg/kg and 94 mg/kg. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 31.4 mg/mL (100.04 mM), Sonication is recommended. DMSO : 40 mg/mL (127.44 mM), Sonication is recommended. |
| Keywords | Wy-45030 | Wy45030 | Wy 45030 Hydrochloride | Wy 45030 | Venlafaxine Hydrochloride | Venlafaxine hydrochloride | Venlafaxine | SLC6A4 | SERT | SerotoninTransporter | Serotonin Transporter | serotonin | reuptake | norepinephrine | Inhibitor | inhibit | antidepressant | 5-HTT | 5HTReceptor | 5HT Receptor | 5-HT |
| Inhibitors Related | Alverine citrate | Olanzapine | Dapoxetine hydrochloride | Clozapine N-Oxide | Mirtazapine | D-Menthol | Amitriptyline hydrochloride | Cloperastine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | Cinchonidine |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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