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Postion:Product Catalog >Tuxobertinib
Tuxobertinib
  • Tuxobertinib

Tuxobertinib NEW

Price $55 $97 $198
Package 5mg 10mg 25mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-05-26

Product Details

Product Name: Tuxobertinib CAS No.: 2414572-47-5
Purity: 99.22% Supply Ability: 10g
Release date: 2025/05/26

Product Introduction

Bioactivity

NameTuxobertinib
DescriptionTuxobertinib (BDTX-189) is a potent and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, with KDs of 0.2, 0.76, 13, and 1.2 nM for EGFR, HER2, BLK, and RIPK2, respectively, and exhibits anticancer activity.
In vivoBDTX-189 (0-100 mg/kg;?p.o.;?daily for 15 dyas) shows dose-dependent tumor growth inhibition and regression in in athymic nude mice bearing HER2 S310F Ba/F3 allograft tumors.?BDTX-189 (1-50 mg/kg.p.o.;?daily for 15 days) shows dose-dependent tumor growth inhibition and regression in athymic nude mice bearing CUTO-14 PDX tumors that express the EGFR mutation EGFR ASV
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility InformationDMSO : 41.67 mg/mL (74.27 mM), Sonication is recommended.
KeywordsTuxobertinib | RIPkinase | RIPK2 | RIP kinase | oral | oncogene athymic | nude | mutants | mice | insertion | Inhibitor | inhibit | HER2 | HER1 | ErbB-1 | Epidermal growth factor receptor | EGFR | BLK | BDTX189 | BDTX 189 | Ba/F3 | allosteric
Inhibitors Related(S)-Afatinib | Tannic acid | Osimertinib | Lidocaine Hydrochloride hydrate | Oditrasertib | Lapatinib | Erlotinib hydrochloride | Erlotinib | Neratinib | Afatinib | Genistein | Gefitinib
Related Compound LibrariesFailed Clinical Trials Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | Tyrosine Kinase Inhibitor Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library | Anti-Cancer Active Compound Library

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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