Chemical Name：L-Arginyl-L-lysyl-L-aspartyl-L-valyl-L-tyrosine/Thymopentin

CAS：69558-55-0

Molecular Formula：C₃₀H₄₉N₉O₉

Molecular Weight：679.77 g/mol

Appearance：White to off-white lyophilized powder

Solubility：Freely soluble in water; insoluble in organic solvents (e.g., ethanol, acetone)

Stability：Stable at 2–8°C; protect from light and moisture

Mode of Action：Immunomodulatory peptide; binds to CD4+ T-cells, enhancing immune response.

Pharmacological Use：Treatment of immunodeficiency disorders (e.g., HIV, post-chemotherapy recovery).

Half-life：~30 minutes (rapid clearance)

Thymopentin is a synthetic pentapeptide derived from the active site of thymopoietin, a thymic hormone. It functions as an immune system modulator by:

Stimulating T-cell differentiation and maturation.

Enhancing lymphocyte activity in immunocompromised patients.

Restoring immune function after chemotherapy or chronic infections.

Clinical Applications:

Adjuvant therapy for HIV/AIDS (CD4+ T-cell recovery).

Post-operative immune support (e.g., cancer patients).

Autoimmune diseases (e.g., rheumatoid arthritis) in research.

Advantages:

Low molecular weight → rapid absorption.

Minimal side effects (vs. full thymic extracts).

Key Features

Sequence: Arg-Lys-Asp-Val-Tyr (position 32-36 of thymopoietin).

Administration: Subcutaneous or intramuscular injection.

Storage: Lyophilized powder stable for 24 months at 2–8°C.