TGR5 Receptor Agonist NEW
| Price | $34 | $79 | $133 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-30 |
Product Details
| Product Name: TGR5 Receptor Agonist | CAS No.: 1197300-24-5 |
| Purity: 99.77% | Supply Ability: 10g |
| Release date: 2025/04/30 |
Product Introduction
Bioactivity
| Name | TGR5 Receptor Agonist |
| Description | TGR5 is a potent TGR5(GPCR19) agonist. |
| Kinase Assay | Inhibition assays are carried out in 384-well white ProxiPlates in 10 μL of reaction volume. Standard reaction mixtures consisted of the compound (in 2% DMSO final concentration), enzyme mix (0.001 μM of PHD2, 10 μM of Fe(II), 100 μM of ascorbate) and peptide mix (0.06 μM of biotinylated C-terminal oxygen dependent degradation domain (CODD) peptide, 2 μM of 2OG) in 50 mM HEPES pH 7.5, 0.01% Tween-20 and 0.1% BSA buffer. Compounds (e.g., IOX2) are preincubated with the enzyme mix for 15 min before being incubated with peptide mix for 10 min at 22°C. Each reaction is quenched with 5 μL of 30 mM EDTA. The bead mix containing AlphaScreen beads is preincubated for 1h with a rabbit monoclonal antibody selective for hydroxy-HIF1α (Pro564) and are added to the wells for a further 1 h at 22°C. The plates are then analyzed with an Envision plate reader. The IC50 values are calculated using nonlinear regression with normalized dose-response fit using Prism GraphPad (n≥3)[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 50 mg/mL (138.42 mM), Sonication is recommended. Ethanol : 100 mM, Sonication is recommended. |
| Keywords | U2-OS cells | TGR5 Receptor Agonist | TGR-5 Receptor Agonist | TGR5 Receptor Agonist | TGR5 | melanophore cells | Inhibitor | inhibit | G-protein coupled receptor 19 | GPCR19 | GPBAR1 | G protein-coupled Bile Acid Receptor 1 | diabetes | CCDC | Calcium Channel | Ca2+ channels | Ca channels | C57BL/6J mice | bladder hypersensitivity | anti-obesity |
| Inhibitors Related | Ursodeoxycholic acid sodium | SBI-115 | BAR502 | TC-G 1005 | Deoxycholic acid | Triamterene | L-692429 | Deoxycholic acid sodium salt | BAR501 | Hyodeoxycholic acid | PEN (human) aceate | SB756050 |
| Related Compound Libraries | Target-Focused Phenotypic Screening Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Anti-Obesity Compound Library | NO PAINS Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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