STAT3-IN-18 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-02 |
Product Details
| Product Name: STAT3-IN-18 | CAS No.: 2668267-41-0 |
| Supply Ability: 10g | Release date: 2025/05/02 |
Product Introduction
Bioactivity
| Name | STAT3-IN-18 |
| Description | STAT3-IN-18 (compound SPP), a platinum (IV) complex featuring an axial ligand from sandalwood, suppresses the JAK2-STAT3 pathway in breast cancer (BC) cells and exhibits anti-proliferative properties. It promotes apoptosis by activating caspase-3 and elevating levels of cleaved polyADP-ribose polymerase, in addition to enhancing maturation and antigen presentation in dendritic cells. Moreover, STAT3-IN-18 has demonstrated in vivo safety. |
| In vitro | STAT3-IN-18 at a concentration of 0.5 μM for 48 hours inhibits the phosphorylation of STAT3 and JAK2 in MDA-MB-231 cells, reduces the protein levels of Bcl-2 and COX-2, and increases the protein levels of Bak, Caspase-3, and Cleaved-PARP1 [1]. Additionally, STAT3-IN-18 at 0.5 μM for 36 hours induces cell cycle arrest at the S phase and promotes apoptosis in MDA-MB-231 cells after 48 hours of treatment. |
| In vivo | STAT3-IN-18, administered bi-daily at an equivalent dose of 1.5 mg Pt for a total of 18 days, inhibited STAT3 phosphorylation and suppressed tumor growth in the 4T1 xenograft mouse model. The median lethal dose (LD50) of STAT3-IN-18 was determined to be 10.45 mg/kg [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Inhibitors Related | Delgocitinib | Deucravacitinib | RO8191 | Ruxolitinib | Tofacitinib Citrate | CEP-33779 | G5-7 | Ruxolitinib phosphate | JAK-IN-10 | WHI-P97 | Fedratinib | TAK-901 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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