S-Adenosyl-L-methionine (1,4-butanedisulfonate) NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: S-Adenosyl-L-methionine (1,4-butanedisulfonate) | CAS No.: 200393-05-1 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | S-Adenosyl-L-methionine (1,4-butanedisulfonate) |
| Description | S-Adenosyl-L-methionine (SAMe) 1,4-butanedisulfonate functions as an orally active methyl group donor and serves as a dietary supplement known for its significant antidepressant properties. Additionally, it plays anti-proliferative, pro-apoptotic, and anti-metastatic roles in cancer. SAMe 1,4-butanedisulfonate holds promise in research pertaining to cancer, liver disease, and osteoarthritis [1] [2] [3]. |
| In vitro | S-Adenosyl-L-methionine at a concentration of 300 μM for 24 or 48 hours in its 1,4-butanedisulfonate form induces apoptosis and facilitates cell cycle arrest in Cal-33 and JHU-SCC-011 cells [4]. Similarly, S-Adenosyl-L-methionine (300 μM, 24 h) 1,4-butanedisulfonate reduces migration in both Cal-33 and JHU-SCC-011 cell lines [4]. Additionally, when administered at doses ranging from 5 to 40 μg/mL for 48 hours, 1,4-butanedisulfonate-derivative S-Adenosyl-L-methionine modulates the expression of DNMTs, thereby preserving the anticancer efficacy of 5-FU [5]. |
| In vivo | S-Adenosyl-L-methionine (30 mg/kg, orally administered for 3 consecutive days) 1,4-butanedisulfonate has been shown to prevent ASD-like behaviors induced by early postnatal valproate exposure in young mice [6]. At doses of 50 and 100 mg/kg administered orally, 1,4-butanedisulfonate also exhibits antiepileptic, memory-enhancing, and antioxidant properties in a pentylenetetrazole-induced rat model of epilepsy [7]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Keywords | EndogenousMetabolite | Endogenous Metabolite |
| Inhibitors Related | Sucrose | Cysteamine hydrochloride | D(+)-Raffinose pentahydrate | Daidzein | Guanidine hydrochloride | Fumaric acid | Ferulic Acid | Formamide | Glycerol | Thymidine | Naringin | 3-Indoleacetic acid |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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