
RO2959 Hydrochloride NEW
Price | $79 | $173 | $256 |
Package | 1mg | 5mg | 10mg |
Min. Order: | |
Supply Ability: | 10g |
Update Time: | 2025-05-16 |
Product Details
Product Name: RO2959 Hydrochloride | CAS No.: 1219927-22-6 |
Purity: 97.42% | Supply Ability: 10g |
Release date: 2025/05/16 |
Product Introduction
Bioactivity
Name | RO2959 Hydrochloride |
Description | RO2959 Hydrochloride (RO2959 HCl) is a potent and selective inhibitor of CRAC channel(IC50: 402 nM). It is also a potent inhibitor of human IL-2. |
In vitro | RO2959 is a potent SOCE inhibitor that blocked an IP3-dependent current in CRAC-expressing RBL-2H3 cells and CHO cells stably expressing human Orai1 and Stim1, as well as SOCE in human primary CD4+ T cells triggered by either TCR stimulation or thapsigargin treatment. RO2959 completely inhibited cytokine production as well as T cell proliferation mediated by TCR stimulation or MLR (mixed lymphocyte reaction). |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO : 10 mg/mL (21.55 mM), Sonication is recommended. |
Keywords | T-cell | Stim1 | SOCE | RO-2959 Hydrochloride | RO2959 Hydrochloride | RO-2959 | RO2959 | RO 2959 Hydrochloride | RO 2959 | Orai1 | IP3 | Interleukin Related | Interleukin | Inhibitor | inhibit | ILReceptor | IL-2 | IL Receptor | heart | failure | CRAC channel | CRAC Channel | CalciumChannel | Calcium release-activated channels | Calcium Channel | Ca2+ release-activated Ca2+ channels | anti-proliferation |
Inhibitors Related | Sodium Thiocyanate | Inosine pranobex | Amlexanox | L-Ascorbic acid | L-Phenylalanine | D-Menthol | Ethyl cinnamate | Dexamethasone | L-Ascorbic acid sodium salt | 1-Octanol | Diallyl disulfide | 2-Nitrobenzoic acid |
Related Compound Libraries | Bioactive Compound Library | Pain-Related Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Neuroprotective Compound Library | Inhibitor Library | Metabolism Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | Fluorochemical Library | Ion Channel Targeted Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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- Address: 36 Washington Street, Wellesley Hill, MA
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