Ranolazine dihydrochloride NEW
| Price | $62 | $158 |
| Package | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: Ranolazine dihydrochloride | CAS No.: 95635-56-6 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | Ranolazine dihydrochloride |
| Description | Ranolazine dihydrochloride (Ranolazine 2HCl) , an antianginal agent, can treat arrhythmia via a novel mechanism of action (inhibition of the late phase of the inward sodium current), and do not affect blood pressure or heart rate. |
| In vitro | Ranolazine (5 mM and 10 mM) reversibly shortened the duration of twitch contractions and abolished postcontractions.Ranolazine bound more to sodium channels in the inactivated state. In cardiomyocytes, selective inhibition of late I (sodium) by Ranolazine reduced sodium-dependent calcium overload and attenuated ventricular repolarization and contraction, which correlated with abnormalities in heart failure and ischemia/reperfusion injury. In dog left ventricular myocytes, in a concentration-dependent manner Ranolazine was able to reversibly shorten myocyte action potential duration in response to 0.25/0.5 Hz stimulation. |
| In vivo | Ranolazine (5 mM and 10 mM) reversibly shortened the duration of twitch contractions and abolished postcontractions.Ranolazine bound more to sodium channels in the inactivated state. In cardiomyocytes, selective inhibition of late I (sodium) by Ranolazine reduced sodium-dependent calcium overload and attenuated ventricular repolarization and contraction, which correlated with abnormalities in heart failure and ischemia/reperfusion injury. In dog left ventricular myocytes, in a concentration-dependent manner Ranolazine was able to reversibly shorten myocyte action potential duration in response to 0.25/0.5 Hz stimulation. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 45 mg/mL (89.92 mM), Sonication is recommended. H2O : 50.1 mg/mL (100.11 mM), Sonication is recommended. |
| Keywords | SodiumChannel | Sodium Channel | RS-43285 | RS43285 | Ranolazine Dihydrochloride | Ranolazine dihydrochloride | Ranolazine | Na+ channels | Na channels | Inhibitor | inhibit | CVT-303 | CVT303 | CVT 303 | CalciumChannel | Calcium Channel | Ca2+ channels | Ca channels | Autophagy |
| Inhibitors Related | Stavudine | Phenytoin sodium | Sodium 4-phenylbutyrate | L-Ascorbic acid | Hydroxychloroquine | Guanidine hydrochloride | Taurine | Valproic Acid | Paeonol | Naringin | L-Ascorbic acid sodium salt | Gefitinib |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Inhibitor Library | Neuroprotective Compound Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Ion Channel Targeted Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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