Procaine hydrochloride NEW
| Price | $31 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-06 |
Product Details
| Product Name: Procaine hydrochloride | CAS No.: 51-05-8 |
| Purity: 100% | Supply Ability: 10g |
| Release date: 2025/05/06 |
Product Introduction
Bioactivity
| Name | Procaine hydrochloride |
| Description | Procaine hydrochloride (Novocaine HCl) is the hydrochloride salt form of procaine, a benzoic acid derivative with local anesthetic and antiarrhythmic properties. Procaine binds to and inhibits voltage-gated sodiumchannels, thereby inhibiting the ionic flux required for the initiation and conduction of impulses. In addition, this agent increases electrical excitation threshold, reduces rate of rise of action potential and slows nerve impulse propagation thereby causing loss of sensation. |
| In vitro | In anesthetized cats, Procaine (15 mg/kg) enhanced the cellular activity in the ventral hippocampal formation of the amygdala, the ventromedial hypothalamus, the septal nucleus, and the neocortex of the temporal lobe. Procaine acts as a stimulant for marginal system cells. Furthermore, Procaine facilitates the conduction of evoked stimulatory activity from the amygdala to the ventromedial hypothalamus. |
| In vivo | Procaine exhibits the ability to bind to or antagonize nicotinic acetylcholine receptors and the 5-HT(serotonin) receptor-ion channel complex, as well as N-methyl-D-aspartate (NMDA) receptors. Its primary mechanism of action involves the inhibition of sodium ion influx by affecting the voltage-gated sodium channels on the neuronal cell membranes of peripheral nerves. This disruption of sodium ion flow prevents the generation of action potentials, thereby inhibiting signal transduction. Studies suggest that the receptor sites targeted by procaine are located on the cytoplasmic (internal) portion of the sodium channels. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 55 mg/mL (201.64 mM), Sonication is recommended. H2O : 50 mg/mL (183.3 mM), Sonication is recommended. |
| Keywords | targets | SodiumChannel | Sodium channel | Sodium Channel | RNASynthesis | RNA Synthesis | Procaine hydrochloride | Procaine Hydrochloride | Procaine | onset | NMDA receptor | nAChR | multiple | Inhibitor | inhibit | HistoneDemethylase | Histone Demethylase | duration | DNASynthesis | DNA/RNA Synthesis | DNA Synthesis | 5HTReceptor | 5-HT3 | 5HT Receptor |
| Inhibitors Related | 5-Fluorouracil | Phenytoin sodium | Alverine citrate | Procaine | Dapoxetine hydrochloride | Urethane | Guanidine hydrochloride | Methotrexate disodium | Valproic Acid | Lidocaine hydrochloride | L-Aspartic aicd sodium | Thymidine |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
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