Pioglitazone NEW
| Price | $35 | $48 | $63 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Pioglitazone | CAS No.: 111025-46-8 |
| Purity: 99.46% | Supply Ability: 10g |
| Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Pioglitazone |
| Description | Pioglitazone (U 72107) is an insulin sensitizing agent and thiazolidinedione indicated for the treatment of type 2 diabetes, and has been linked to rare instances of acute liver injury. |
| In vitro | In mouse models of Parkinson's disease (PD) using MPTP, Pioglitazone reduces activation of microglia, inducible nitric oxide synthase (iNOS) positive cells, and glial fibrillary acidic protein (GFAP) positive cells in the striatum and substantia nigra pars compacta. Administering approximately 20 mg/kg of Pioglitazone daily attenuates MPTP-induced neuroglial activation and prevents the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Additionally, in 10-month-old APPV717I transgenic mice, Pioglitazone decreases the number of activated microglia and reactive astrocytes in the hippocampus and cortex. Pioglitazone also reduces mRNA and protein levels of beta-secretase-1 (BACE1), as well as the levels of soluble Abeta1-42 peptide. |
| In vivo | Pioglitazone is primarily metabolized by CYP2C8, with secondary metabolism by CYP3A4. |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 13.33 mg/mL (37.41 mM), Sonication is recommended. Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : < 1 mg/mL (insoluble or slightly soluble) |
| Keywords | U-72107 | U72107 | PPARγ | PPAR | Pioglitazone | Peroxisome proliferator-activated receptors | ligand-binding | Inhibitor | inhibit | Ferroptosis | domain | diabete | blood glucose |
| Inhibitors Related | TBHQ | Acetylcysteine | α-Vitamin E | Daidzein | L-Glutamic acid | Sorafenib | Curcumin | L-Cystine | L-Glutamine | L-Glutamic acid monosodium salt | Naringenin | 2,3-Butanediol |
| Related Compound Libraries | Failed Clinical Trials Compound Library | Bioactive Compound Library | Anti-Neurodegenerative Disease Compound Library | EMA Approved Drug Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Anti-Cancer Approved Drug Library | FDA-Approved Drug Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Cancer Drug Library |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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