Patritumab deruxtecan NEW
| Price | $797 | $2320 | $3480 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-02 |
Product Details
| Product Name: Patritumab deruxtecan | CAS No.: 2227102-46-5 |
| Purity: 95% | Supply Ability: 10g |
| Release date: 2025/05/02 |
Product Introduction
Bioactivity
| Name | Patritumab deruxtecan |
| Description | Patritumab deruxtecan (HER3-DXd) is an antibody-drug coupling (ADC) targeting HER3 consisting of a fully humanized anti-HER3 IgG1 monoclonal antibody linked via a cleavable tetrapeptide linker to a topoisomerase I inhibitor payload (an ezetiocan derivative, DXd) for the study of non-small cell lung cancer (NSCLC). |
| In vitro | Patritumab deruxtecan is an investigational HER3-directed antibody-drug conjugate composed of a human immunoglobulin G1 monoclonal antibody (patritumab) directed against HER3 covalently linked to a topoisomerase I inhibitor payload via a tetrapeptide-based cleavable linker. Upon binding to HER3, HER3-DXd translocates to lysosomes, where the linker is cleaved by lysosomal enzymes that are upregulated in tumor cells. The cytotoxic payload is then free to enter the nucleus, leading to cell death and, because the payload is membrane permeable, has potential bystander antitumor effects. [1] |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. |
| Keywords | Patritumab deruxtecan | AntibodyDrugConjugates(ADCs) | AntibodyDrugConjugates | AntibodyDrug Conjugates (ADCs) | Antibody-Drug Conjugates | ADCs |
| Inhibitors Related | Belantamab | Trastuzumab | Daratumumab | Tamrintamab | Raludotatug deruxtecan | Enfortumab | Inebilizumab | Lonigutamab | Sacituzumab | Cantuzumab | lorvotuzumab | Glembatumumab |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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