NSC305787 NEW
| Price | $347 | $1140 | $1490 |
| Package | 5mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-09 |
Product Details
| Product Name: NSC305787 | CAS No.: 785718-37-8 |
| Purity: 99.40% | Supply Ability: 10g |
| Release date: 2025/05/09 |
Product Introduction
Bioactivity
| Name | NSC305787 |
| Description | NSC305787 is an ezrin inhibitor with antitumor activity, inhibits PKCΙ-induced ezrin phosphorylation, reduces β2AR expression in the cell membrane, and induces intracellular vesicular or punctate expression of ezrin and β2AR, and can be used to study pancreatic cancer. |
| In vitro | NSC305787 is a small molecule inhibitor that specifically targets ezrin with a binding dissociation constant (Kd) of 5.85 μM and shows significant anti-tumor effects. The compound exhibited different inhibitory activities by inhibiting the phosphorylation of ezrin, moesin, radixin, and MBP by PKCI with IC50 values of 8.3 μM, 9.4 μM, 55 μM, and 58.9 μM, respectively.Although NSC305787 was also bound to PKCI (Kd=172.4 μM), it inhibited ezrin mainly through direct binding to ezrin. Although NSC305787 also binds to PKCI (Kd=172.4 μM), it mainly inhibits the phosphorylation of ezrin T567 by directly binding to ezrin, rather than by blocking PKCI kinase activity. In cellular assays, NSC305787 significantly inhibited the ezrin-mediated invasion of K7M2 osteosarcoma cells at concentrations of 1 μM and 10 μM. In addition, NSC305787 was able to reduce the cell motility phenotype in zebrafish at a concentration of 10 μM and effectively blocked the metastatic growth of osteosarcoma in lung organ culture. [1] |
| In vivo | In in vivo experiments, NSC305787 (0.240 mg/kg/day, intraperitoneal injection) significantly inhibited the growth of ezrin-dependent osteosarcoma metastases in the lungs of mice. [1] In a transgenic osteosarcoma mouse model (Osx-Cre+p53fl/flpRBfl/fl), NSC305787 (240 μg/kg, intraperitoneal injection) also significantly inhibited lung metastasis while demonstrating superior pharmacokinetic properties to NSC305787. [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 4 mg/mL (8.98 mM), Sonication and heating are recommended. |
| Keywords | NSC-305787 | NSC305787 | NSC 305787 |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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