Ledipasvir hydrochloride NEW
| Price | $2420 | $3180 | $4300 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Ledipasvir hydrochloride | CAS No.: 2128695-48-5 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Ledipasvir hydrochloride |
| Description | Ledipasvir hydrochloride (GS-5885) is a hepatitis C virus NS5A inhibitor, demonstrating potent activity with EC50 values of 34 pM for genotype 1a replicon and 4 pM for genotype 1b replicon. It also functions as a SARS-CoV 3CL pro inhibitor with an IC50 of 1.62 μM [3]. |
| In vitro | Ledipasvir hydrochloride exhibits potent antiviral activity with EC50 values of 31 pM for GT1a and 4 pM for GT1b. When protein-adjusted, these values rise to 210 pM for GT1a and 27 pM for GT1b. The compound's intrinsic EC50 for GT1a is 310 fM and for GT1b is 40 fM. It is noted for high protein binding in both human serum and 10% BSA-containing cell-culture media used in replicon assays [1]. Additionally, ledipasvir hydrochloride demonstrates an EC50 value of 141 nM against the JFH/3a-NS5A replicon [2]. |
| In vivo | Ledipasvir hydrochloride is distinguished by its potent replicon inhibition, complemented by low systemic clearance, favorable bioavailability, and extended half-lives in rat (1.83 hr), dog (2.63 hr), and monkey species, with similarly low clearance projected for humans. Its pharmacokinetics reveal moderate volumes of distribution (Vss) exceeding total body water and consistent half-lives in both rat and dog plasma. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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