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Postion:Product Catalog >Ladostigil
Ladostigil
  • Ladostigil

Ladostigil NEW

Price $120 $290 $440
Package 1mg 5mg 10mg
Min. Order:
Supply Ability: 10g
Update Time: 2025-07-16

Product Details

Product Name: Ladostigil CAS No.: 209394-27-4
Purity: 98.79% Supply Ability: 10g
Release date: 2025/07/16

Product Introduction

Bioactivity

NameLadostigil
DescriptionLadostigil (Ladostigil free base) is an orally active dual inhibitor of cholinesterase and brain-selective monoamine oxidase (MAO) with inhibitory effects on MAO-B and AChE, with IC50 values of 37.1 and 31.8 μM, respectively.Ladostigil possesses anti-inflammatory, antioxidant, and neuroprotective activities, and may be used in studies of depression and Alzheimer's disease.
In vitroLadostigil (1-10 μM) demonstrates neuroprotective effects by preventing the decline in mitochondrial membrane potential (ψ), reducing apoptotic cascades, and inhibiting the production of reactive oxygen species (ROS) induced by OS insults.[6] Ladostigil (1-10 μM) exhibits notable neuroprotective effects in human neuroblastoma SK-N-SH cells. These effects involve the inhibition of caspase-3 activation, upregulation of Bcl-2 expression, and downregulation of Bad and Bax gene and protein expression.[6]
In vivoLadostigil (17 mg/kg; p.o. daily for 6 weeks) eliminates hyperanxiety and depressive-like behavior in adult rats exposed to prenatal stress, as shown in the elevated plus maze (EPM) and forced swim tests (FST).[8] Ladostigil (50 μmol/kg; single p.o.) also restores episodic memory in the object recognition test in rats.[7]
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility InformationDMSO : 4.8 mg/mL (17.63 mM), Sonication is recommended.
KeywordsMAO-B | Antioxidant | AChE
Inhibitors RelatedThiamine monochloride | Butylated hydroxytoluene | AFMK | L-Tartaric acid | Diethyltoluamide | 1,4-Naphthoquinone | Neohesperidin | Sulbutiamine | Paeonol | L-Cystine | 6-PPD | 4-hydroxyphenylacetic acid
Related Compound LibrariesMitochondrial Membrane Protein-Targeted Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Membrane Protein-targeted Compound Library | Drug Repurposing Compound Library | Neuroprotective Compound Library | Inhibitor Library | Mitochondria-Targeted Compound Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max

Company Profile Introduction

Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers. TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.

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