Ivabradine hydrochloride NEW
| Price | $33 | $50 | $68 |
| Package | 10mg | 25mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-29 |
Product Details
| Product Name: Ivabradine hydrochloride | CAS No.: 148849-67-6 |
| Purity: 99.73% | Supply Ability: 10g |
| Release date: 2025/07/29 |
Product Introduction
Bioactivity
| Name | Ivabradine hydrochloride |
| Description | Ivabradine hydrochloride (S 16257-2) is a new If inhibitor (IC50: 2.9 μM). Ivabradine Hydrochloride is the hydrochloride salt form of ivabradine, an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker, with negative chronotropic activity. Upon administration, ivabradine selectively binds to the intracellular portion of the HCN channel pore and blocks HCN channels in the pacemaker cells within the sinoatrial (SA) node. This inhibits the If (funny) pacemaker ion current, prevents the inward flow and intracellular accumulation of positively charged ions, reduces pacemaker activity and slows diastolic depolarization. |
| In vivo | Ivabradine treatment (10 mg/kg/d) induces long-term HRR, and that improves diastolic LV function probably involving attenuated hypoxia, reduced remodeling, and/or preserved nitric oxide bioavailability, resulting from processes triggered early after HRR initiation: angiogenesis and/or preservation of endothelial nitric oxide synthase expression[1]. Ivabradine causes a sustained 15-20% heart rate reduction, but has no effect on blood pressure. While ivabradine has no effect on endothelial function and vascular reactive oxygen species production in angiotensin II-treated rats, it improves both parameters in ApoE knockout mice. Ivabradine treatment leads to an attenuation of angiotensin II signaling and increased the expression of telomere-stabilizing proteins in ApoE knockout mice, which may explain its beneficial effects on the vasculature. The absence of these protective ivabradine effects in angiotensin II-infused rats may relate to the treatment duration or the presence of arterial hypertension[2]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 93 mg/mL (184.14 mM), Sonication is recommended. Ethanol : 93 mg/mL (184.14 mM), Sonication is recommended. H2O : 75 mg/mL (148.5 mM), Sonication is recommended. |
| Keywords | orally active | Ivabradine Hydrochloride | Ivabradine hydrochloride | Ivabradine | Inhibitor | inhibit | Hyperpolarization activated cyclic nucleotide gated channels | heart rate | HCNChannel | HCN Channel | anti-ischaemic | anticonvulsant | anti-anginal | AdrenergicReceptor | Adrenergic Receptor |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Tolazoline hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride |
| Related Compound Libraries | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Membrane Protein-targeted Compound Library | EMA Approved Drug Library | Drug Repurposing Compound Library | Inhibitor Library | FDA-Approved Drug Library | Anti-Cancer Approved Drug Library | Bioactive Compounds Library Max | Ion Channel Targeted Library | GPCR Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $1.00/1kg |
VIP3Y
|
Wuhan Haorong Biotechnology Co.,Ltd
|
2025-07-09 | |
| $5.00/1KG |
VIP1Y
|
Wuhan JiyunZen Tech Co., Ltd.
|
2025-06-05 | |
| $0.00/25KG |
VIP1Y
|
Shaanxi Dideu New Materials Co. Ltd
|
2025-05-21 | |
| $0.00/1g |
VIP2Y
|
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
|
2024-09-19 | |
| $0.00/1kg |
VIP3Y
|
Hebei Kingfiner Technology Development Co.Ltd
|
2023-12-19 | |
| $50.00/1kg |
Hebei Yanxi Chemical Co., Ltd.
|
2023-10-20 | ||
| $50.00/1kg |
Anhui Ruihan Technology Co., Ltd
|
2023-09-21 | ||
| $30.00/1kg |
Henan Bao Enluo International TradeCo.，LTD
|
2023-08-18 | ||
| $0.00/25kg |
VIP3Y
|
Chengdu ChenLv Herb Co.,Ltd
|
2023-08-08 | |
| $24.50/1KG |
Hong Kong Tiansheng New Material Trading Co., Ltd
|
2022-01-11 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY