Istaroxime hydrochloride NEW
| Price | $134 | $229 | $789 |
| Package | 2mg | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-28 |
Product Details
| Product Name: Istaroxime hydrochloride | CAS No.: 374559-48-5 |
| Supply Ability: 10g | Release date: 2025/04/28 |
Product Introduction
Bioactivity
| Name | Istaroxime hydrochloride |
| Description | Istaroxime hydrochloride (PST2744 hydrochloride) is a Na+/K+-ATPase inhibitor and sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator, a novel positive inotropic compound that can be used to study acute heart failure. |
| In vitro | Istaroxime hydrochloride acts as a positive inotropic drug by inhibiting Na+,K+-ATPase. [1] The IC50 value of Istaroxime hydrochloride for inhibition of Na+/K+-ATPase activity in dog kidney was 0.43 μM. In guinea-pig kidney tissue preparations, the potency of Istaroxime hydrochloride for inhibition of Na+/K+-ATPase activity was 8.5 μM. [2] |
| In vivo | Istaroxime hydrochloride progressively elevated +dP/dtmax throughout the infusion period, achieving an 80% effect at a cumulative dose of 1.89 ± 0.37 mg/kg (ED80) and reaching a peak effect of 140 ± 3.5% at a dose increase to 4.88 ± 0.6 mg/kg (EDmax). [2] |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 20 mg/mL(50.38 mM), Sonication is recommended. DMSO : 40 mg/mL(100.77 mM), Sonication is recommended. |
| Keywords | Na+/K+-ATPase | Na+,K+-ATPase | Istaroxime Hydrochloride |
| Inhibitors Related | Sodium oleate | DHQ | Ciclopirox | trans-Aconitic acid | Phlorizin | Ginsenoside Rb1 | Chlorpropamide | Esomeprazole Magnesium | Revaprazan hydrochloride | Oleic acid | Esomeprazole Sodium | Trichlormethiazide |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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