Fisetin NEW
| Price | $41 |
| Package | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-30 |
Product Details
| Product Name: Fisetin | CAS No.: 528-48-3 |
| Purity: 98.31% | Supply Ability: 10g |
| Release date: 2025/05/30 |
Product Introduction
Bioactivity
| Name | Fisetin |
| Description | Fisetin belongs to a group of natural flavonols with a variety of biological activities, including anti-inflammatory, antioxidant, anti-tumor, anti-aging and neuroprotective effects. |
| In vitro | METHODS: Human pancreatic cancer cells PANC-1 were treated with Fisetin (25-400 μM) for 24-48 h. Cell viability was measured by CCK-8 assay. RESULTS: Low concentrations of Fisetin (25-50 μM) did not significantly inhibit the viability of PANC-1 cells, and high concentrations inhibited it. [1] METHODS: HeLa cells were treated with Fisetin (20-50 μM) for 24-48 h. Cell cycle was detected by Flow cytometry. RESULTS: Cells treated with 20/30/50 μM Fisetin resulted in a high accumulation of G2/M phase cells. The proportion of G2/M-arrested cells increased from 10.1% to 16.2%, 18.9% and 25.1%, respectively, at 24 h, whereas the proportion of G2/M-blocked cells increased to 30.9%, 36.2% and 56.2%, respectively, at 48 h. Meanwhile, at 48 h, 50 μM of Fisetin put a large proportion of cells in Go/G1 phase. [2] |
| In vivo | METHODS: To detect anti-tumor activity in vivo, Fisetin (300 mg/kg) was administered intraperitoneally every two days for 20 days to BALB/c nude mice bearing PANC-1 xenografts. RESULTS: Tumor size was significantly reduced in Fisetin-treated mice. proliferation-associated protein proliferating cell nuclear antigen (PCNA) was significantly reduced in the Fisetin-treated group. fisetin treatment reduced the expression of proteins associated with cell growth and proliferation, including PCNA, Ki67, and phosphorylated histone H3. [1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 28.6 mg/mL (99.92 mM), Sonication is recommended. 10% DMSO+40% PEG300+5% Tween 80+45% Saline : 2.86 mg/mL (9.99 mM), Solution. Ethanol : 2.9 mg/mL (10.13 mM), Sonication is recommended. |
| Keywords | Tumor Necrosis Factor Receptor | TNFR | TNF Receptor | Sirtuin | SIRT | PPAR | Peroxisome proliferator-activated receptors | Inhibitor | inhibit | Fisetin |
| Inhibitors Related | Rosiglitazone | Retinoic acid | Acetylcysteine | Daidzein | Fenofibrate | Glucosamine | Apremilast | 5-Aminosalicylic Acid | Naringenin | Lenalidomide | 2,3-Butanediol | Nicotinamide |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Flavonoid Natural Product Library | Bioactive Compound Library | Traditional Chinese Medicine Monomer Library | Flavor Compound Library | Selected Plant-Sourced Compound Library | Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Natural Product Library | Anti-Aging Compound Library | Cosmetic Ingredient Compound Library | Bitter Compound library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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