FGFR4-IN-5 NEW
| Price | $1670 | $2180 | $2800 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-28 |
Product Details
| Product Name: FGFR4-IN-5 | CAS No.: 1628793-01-0 |
| Supply Ability: 10g | Release date: 2025/07/28 |
Product Introduction
Bioactivity
| Name | FGFR4-IN-5 |
| Description | FGFR4-IN-5, a covalent FGFR4 inhibitor, demonstrates potency and selectivity with an IC50 value of 6.5 nM. Exhibiting significant in vivo anti-tumor activity, it is applicable for research in hepatocellular carcinoma [1]. |
| In vivo | FGFR4-IN-5, administered via oral gavage at 10 mg/kg (single dose), shows high Cmax and low clearance, with Cmax values of 423 ng/ml in mice, 588 ng/ml in rats, and 2820 ng/ml in cynomolgus monkeys, and oral bioavailability of 20%, 12%, and 27%, respectively [1]. FGFR4-IN-5 (oral gavage; 100 mg/kg; twice daily; 28 days) demonstrates significant antitumor activity in an orthotopic Hep3B HTX model [1]. FGFR4-IN-5 (oral gavage; 10, 30, and 100 mg/kg; twice daily; 11 days) induces dose-dependent tumor growth inhibition, with regression at 30 and 100 mg/kg and %δT/δC values of 67% and 70%, respectively, while sorafenib (100 mg/kg; once daily) shows no in vivo benefit [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 100 mg/mL (192.17 mM), Sonication is recommended. |
| Keywords | FGFR4 IN 5 | FGFR-4-IN-5 | FGFR4IN5 |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, USA
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