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Postion:Product Catalog >Exatecan Impurity2
Exatecan Impurity2
  • Exatecan Impurity2
  • Exatecan Impurity2
  • Exatecan Impurity2
  • Exatecan Impurity2
  • Exatecan Impurity2

Exatecan Impurity2 NEW

Price Get Latest Price
Package 10mg 50mg 100mg
Min. Order: 10mg
Supply Ability: 1000
Update Time: 2025-05-27

Product Details

Product Name: Exatecan Impurity2 CAS No.: 143655-59-8
Min. Order: 10mg Purity: 99%+ HPLC
Supply Ability: 1000 Release date: 2025/05/27

Exatecan Impurity

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  • WhatsAPP: +86 17320513646
    E-mail: anna@molcoo.com

  • Product Information

    • Product Code: E068002

    • English Name: Exatecan Impurity 2

    • English Alias: 2,8-diamino-6-fluoro-5-methyl-3,4-dihydronaphthalen-1(2H)-one

    • CAS Number: 143655-59-8

    • Molecular Formula: C11H13FN2O

    • Molecular Weight: 208.23

  • Advantages:As a reference standard for Exatecan Impurity 2, it features a confirmed chemical structure by NMR and MS, with ≥98.5% purity (HPLC), good stability at 2-8℃ in the dark, and high batch consistency. Suitable for impurity analysis of exatecan API and formulations, providing a reliable reference for quality control.

  • Applications

    • Impurity Detection: Used to develop HPLC methods for detecting Impurity 2 in exatecan, determining LOD and LOQ, and controlling impurity content to meet ICH Q3A standards.

    • Process Optimization: Monitors the formation of Impurity 2 during exatecan synthesis, reducing its content by adjusting reaction conditions (e.g., temperature, catalyst dosage) to improve API purity.

    • Stability Studies: Evaluates the trend of Impurity 2 in accelerated stability tests, providing data for storage conditions and shelf life.

  • Background Description:Exatecan is a topoisomerase I inhibitor for cancer treatment. Impurity 2 may be generated from residual raw materials or side reactions during synthesis, and its presence may affect drug safety and efficacy. Therefore, strict control of Impurity 2 is a key part of exatecan's quality system.

  • Research Status

    • Detection Technology: HPLC-UV with a C18 column (4.6×250mm, 5μm), mobile phase acetonitrile-phosphate buffer (30:70, v/v), detection at 254nm, with LOQ up to 0.05%.

    • Formation Mechanism: Impurity 2 may originate from byproducts of intermediate fluorination or amination reactions, and optimizing reaction sequence and purification processes can reduce its formation.

    • Safety Evaluation: Toxicological studies show the NOAEL of Impurity 2 in rats is 50mg/kg, and drug standards typically set its limit at ≤0.1%.

    NOTE!

    We can also customize related analogues and modified peptides including HPLC, MS, 1H-NMR, MS, HPLC, IR, UV, COA, MSDS.
    This product is intended for laboratory use only!

    WhatsAPP: +86 17320513646
    E-mail: anna@molcoo.com


    NEW IN STOCK!

    The Molcoo Laboratory added drug impurity reference standards, including Baricitinib, Piperazine, Benzylpenicillin, Tranilast and multiple N-Nitroso drug impurities! Now available for immediate delivery! 





Company Profile Introduction

1. Drug standards and drug impurity reference substances: provide more than 20,000 kinds of spot impurity reference substances, with sufficient supply and same-day delivery. We have a professional R&D team and comprehensive quality control testing to ensure product quality and reliability. 2. Customized synthesis of impurities and new molecules: Quickly respond to the customized needs of CDE impurities, stably supply impurities that have established quality standards, and provide customized synthesis services for new compounds in the research and development of innovative drugs. 3. Preparation and separation of unknown impurities: With a professional impurity preparation and separation technical team and SFC preparation and separation instruments, we can solve the problems of impurity preparation in complex projects. 4. Process development of new drug intermediates: provide the supply of new drugs and new molecular impurities, process optimization services, as well as the screening and impurity analysis of commercialization routes. 5. Peptide synthesis: Provide customized peptide synthesis services, and cover all kinds of degradation impurities and process impurities generated in the research and development of peptide drugs. At the same time, it provides comprehensive structural confirmation data and customized testing services.

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