Cycloleucine NEW
| Price | $39 | $55 | $80 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-22 |
Product Details
| Product Name: Cycloleucine | CAS No.: 52-52-8 |
| Purity: 98.13% | Supply Ability: 10g |
| Release date: 2025/05/22 |
Product Introduction
Bioactivity
| Name | Cycloleucine |
| Description | Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic effects. |
| In vitro | Cytostatic (10 μg/mL) inhibits the viability of human KB and mouse L1210s leukemia cell lines. Cycloleucine (4-40 mM; 3 h) blocks internal methylation of viral RNA in B77 transformed chick embryo fibroblasts. Cycloleucine (40 mM; 24 h) blocks the formation of both m6A and the penultimate Gm in B77 38S RNA subunits by greater than 90%[2]. |
| In vivo | Cycloleucine (0.5, 1.0, 2.0, 4 μg/μL; intracerebroventrically) increases time spent in open arms, open arm entries, and extreme arrivals in rats[3]. In Semliki Forest virus strain A7(74) infected and control mice, Cycloleucine reduces thymus and spleen weights[4]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O : 45 mg/mL (348.41 mM), Sonication is recommended. DMSO : < 1 mg/mL (insoluble or slightly soluble), Sonication is recommended. |
| Keywords | transferase | nucleic | NMDA receptor | NMDA | methylations | Ionotropic glutamate receptors | Inhibitor | inhibit | iGluR | glycine | cytostatic | Cycloleucine | ATP | anxiolytic |
| Inhibitors Related | (-)-Aspartic acid | Mephenesin | Quinolinic acid | Urethane | Halothane | Riluzole | Ifenprodil Tartrate | Bupivacaine hydrochloride monohydrate | O-Phospho-L-serine | Procaine hydrochloride | Memantine hydrochloride | UBP551 |
| Related Compound Libraries | Pain-Related Compound Library | Anti-Neurodegenerative Disease Compound Library | Bioactive Compound Library | Neuronal Signaling Compound Library | Antidepressant Compound Library | Neurotransmitter Receptor Compound Library | CNS-Penetrant Compound Library | Neuroprotective Compound Library | Inhibitor Library | Bioactive Compounds Library Max | Human Metabolite Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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