COX-2-IN-6 NEW
| Price | $40 | $98 | $148 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-12 |
Product Details
| Product Name: COX-2-IN-6 | CAS No.: 2756347-91-6 |
| Purity: 99.56% | Supply Ability: 10g |
| Release date: 2025/05/12 |
Product Introduction
Bioactivity
| Name | COX-2-IN-6 |
| Description | COX-2-IN-6 is a potent, selective, and orally available cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 0.84 μM and a Ki of 69 nM.COX-2-IN-6 inhibits COX-2-driven PGE2 synthesis with an IC50 of 0.60 μM.COX-2-IN-6 is used to prevent colorectal cancer. COX-2-IN-6 can be used to prevent colorectal cancer. |
| In vitro | COX-2-IN-6 (Compound 10) inhibits human COX-2/COX-1 enzyme and COX-2/COX-1-driven PGE2 synthesis in HEK293 cells, with IC50 of 0.84 μM、>50 μM、0.60 μM and, >50 μM, respectively.[1] COX-2-IN-6 exhibits stability in human or mouse liver microsomes and hepatocytes in vitro. The T1/2 value of human hepatocytes is 3.1 min, and the T1/2 value of mouse hepatocytes is 3.0 min.[1] |
| In vivo | COX-2-IN-6 (Compound 10) (30, 100, 300 mg/kg; oral; single dose; APCmin/mouse model) inhibits adenoma progression and extends survival in the APCmin/+ mouse model.[1] COX-2-IN-6 (10 mg/kg; oral; single dose; APCmin/+ mouse model) exhibits high colonic exposure (>4300 ng/g) and low systemic exposure (<6 ng/mL), C/P distribution ratio > 1200 in 4 hours.[1] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 60 mg/mL (146.52 mM), Sonication is recommended. |
| Keywords | ProstaglandinReceptor | Prostaglandin Receptor | PGE2 | COX-2 |
| Inhibitors Related | Ibuprofen | Acetaminophen | Salicylamide | Salicin | Diclofenac sodium | Diclofenac Potassium | Meloxicam | Paradol | Indomethacin sodium hydrate | Salicylic acid | Glafenine | Revaprazan hydrochloride |
| Related Compound Libraries | Nonsteroidal Anti-Inflammatory Compound Library | Bioactive Compound Library | Pain-Related Compound Library | Membrane Protein-targeted Compound Library | HIF-1 Signaling Pathway Compound Library | Angiogenesis related Compound Library | Inhibitor Library | Immunology/Inflammation Compound Library | Anti-Aging Compound Library | Bioactive Compounds Library Max | GPCR Compound Library | Anti-Cancer Active Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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