Colletofragarone A2 NEW
| Price | Get Latest Price | |
| Package | 5mg | 50mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-01 |
Product Details
| Product Name: Colletofragarone A2 | CAS No.: 181377-06-0 |
| Supply Ability: 10g | Release date: 2025/05/01 |
Product Introduction
Bioactivity
| Name | Colletofragarone A2 |
| Description | Colletofragarone A2, isolated from the fungus Colletotrichum sp. (13S020), exhibits anti-cancer activity by inhibiting mutant p53 and HSP90. It promotes the degradation and aggregation of mutant p53, in turn suppressing tumor growth in vivo [1]. |
| In vitro | Colletofragarone A2 exhibits selective cytotoxicity towards cells harboring p53 R175H structural mutants, displaying higher efficacy than against other p53 variants, such as DNA-contact mutants, wild-type, or null p53 cells (0.05-5 μM; 72 h). It effectively reduces mutant p53 levels by facilitating its degradation in SK-BR-3 cells with the p53 R175H mutation (2 μM; 8 h). Furthermore, when combined with MG-132 (10 μM), Colletofragarone A2 induces the accumulation of aggregated mutant p53 at concentrations of either 2 or 4 μM over 4 hours. |
| In vivo | Colletofragarone A2, administered intratumorally at 0.35 mM and 100 μL daily for 13 days, significantly reduces tumor growth in mice inoculated with HuCCT1 cells harboring the p53 R175H mutation [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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