CMS-121 NEW
| Price | $61 | $95 | $178 |
| Package | 5mg | 10mg | 25mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-14 |
Product Details
| Product Name: CMS-121 | CAS No.: 1353224-53-9 |
| Purity: 98.71% | Supply Ability: 10g |
| Release date: 2025/05/14 |
Product Introduction
Bioactivity
| Name | CMS-121 |
| Description | CMS-121, a quinolone derivative, is an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage (EC50: 7 nM and 200 nM). CMS-121 shows strong neuroprotective, antioxidative, anti-inflammatory, and renoprotective activities. |
| In vitro | CMS-121 can increase acetyl-CoA in cells. CMS-121 (1 μM; 4 hours; HT22 cells) treatment also increases the phosphorylation of ACC1 at serine 79.[1]. |
| In vivo | CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism. CMS-121 (~20 mg/kg; p.o; daily; for 4 months; female SAMP8 mice) treatment decreases cognitive decline and metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 55 mg/mL (171.14 mM), Sonication is recommended. |
| Keywords | neuroprotective | mitochondrial | Inhibitor | inhibit | H3K9 | disease | dementia | CMS-121 | CMS 121 | antioxidative | anti-inflammatory | Alzheimer's | AcetylCoACarboxylase | Acetyl-CoA carboxylase 1 (ACC1) | Acetyl-CoA Carboxylase | AcetylCoA Carboxylase | acetylation | ACC1 | ACC, Acetyl Coenzyme A Carboxylase |
| Inhibitors Related | ND-646 | Olumacostat Glasaretil | PF-05175157 | PROTAC ACC degrader-1 | Haloxyfop | CP-640186 hydrochloride | Firsocostat | PF-05221304 | CP-640186 | Moiramide B | TOFA | Tralkoxydim |
| Related Compound Libraries | Bioactive Compound Library | Anti-Obesity Compound Library | Antioxidant Compound Library | Neuroprotective Compound Library | Inhibitor Library | Lipid Metabolism Compound Library | Orally Active Compound Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Anti-Hypertension Compound Library | Oxidation-Reduction Compound Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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