CDK1/2/4-IN-1 NEW
| Price | $1520 | $1980 | $2500 |
| Package | 25mg | 50mg | 100mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: CDK1/2/4-IN-1 | CAS No.: 2414633-49-9 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | CDK1/2/4-IN-1 |
| Description | CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78, and 0.87 μM for CDK1, CDK2, and CDK4, respectively. It can be used in cancer research to arrest the cell cycle at the G2/M phase and induce apoptosis, elevating Bax, caspase-3, and P53 levels while decreasing Bcl-2 levels [1]. |
| In vitro | CDK1/2/4-IN-1 (compound 3a), at concentrations between 0.01 and 100 μM over 24 hours, shows antitumor activity in multiple cancer cell lines, including HepG-2 (liver cancer), A549 (lung cancer), and MCF-7 (breast cancer), with IC50 values of 1.56, 1.39, and 1.97 μM respectively [1]. In A549 cells treated with 1.39 μM for 24 hours, it induces G2/M phase cell cycle arrest, apoptosis, and the up-regulation of Bax, caspases-3, p53, and the Bcl-2 ratio [1]. A 2.6-fold increase in the G2/M phase and a significant rise in apoptotic cells confirm the compound's efficacy in promoting cell death and inhibiting cancer cell proliferation [1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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