CC-115 hydrochloride NEW
| Price | $1657 |
| Package | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: CC-115 hydrochloride | CAS No.: 1300118-55-1 |
| Supply Ability: 10g | Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | CC-115 hydrochloride |
| Description | CC-115 hydrochloride is a potent dual inhibitor of DNA-PK (IC50 = 13 nM) and mTOR kinase (IC50 = 21 nM), effectively blocking both mTORC1 and mTORC2 signaling pathways. |
| In vitro | CC-115 effectively inhibits the proliferation of PC-3 cells with an IC50 value of 138 nM. In kinase selectivity screenings at 3 μM against 250 protein kinases, it significantly inhibits only mTOR kinase and one other kinase, cFMS, by 57% (IC50 = 2.0 μM). Among the tested PI3K-related kinases (PIKKs), CC-115 shows equipotency to DNA PK with an IC50 of 15 nM, demonstrating a selectivity range of 40 to >1000 fold over other PIKKs such as PI3K-alpha (IC50 = 0.85 μM), ATR (50% inhibition at 30 μM), and ATM (IC50 >30 μM). Furthermore, CC-115 displays minimal inhibitory activity against CYP enzymes and the hERG ion channel with IC50 values exceeding 10 μM and 33 μM, respectively. In a screening against a Cerep receptor and enzyme panel at 10 μM, CC-115 notably inhibits only one target, PDE3, by more than 50% (IC50 = 0.63 μM) [1]. |
| In vivo | CC-115 hydrochloride demonstrates favorable pharmacokinetic (PK) profiles in vivo across multiple species, achieving oral bioavailability rates of 53%, 76%, and approximately 100% in mice, rats, and dogs, respectively. When administered at doses of 0.25, 0.5, and 1 mg/kg twice daily (bid) or at a single daily dose (qd) of 1 mg/kg, CC-115 leads to notable tumor volume reductions of 46%, 57%, 66%, and 57%, respectively. The compound maintains its inhibitory effect for 24 hours, with significant activity noted at 1 and 3 hours post-administration at a 1 mg/kg dose, and continuous inhibition observable up to 10 hours. CC-115 has been assessed under both once daily (qd) and twice daily (bid) dosing regimens. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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