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Postion:Product Catalog >API>Antineoplastic agents>Antibiotics anticancer drugs>Bleomycin sulfate
Bleomycin sulfate
  • Bleomycin sulfate
  • Bleomycin sulfate
  • Bleomycin sulfate
  • Bleomycin sulfate
  • Bleomycin sulfate

Bleomycin sulfate NEW

Price Get Latest Price
Package 1g 5g 10g
Min. Order: 1g
Supply Ability: 100g
Update Time: 2025-05-23

Product Details

Product Name: Bleomycin sulfate CAS No.: 9041-93-4
EC-No.: 232-925-2 Min. Order: 1g
Purity: 96.3% Supply Ability: 100g
Release date: 2025/05/23

Bleomycin sulfate is a glycopeptide-derived chemotherapeutic agent used primarily to treat cancers, including Hodgkin’s lymphoma, testicular cancer, and squamous cell carcinomas. Key details:

  • Mechanism: Induces DNA strand breaks via free radical formation, blocking cancer cell replication.

  • Administration: Intravenous or intramuscular injection; often combined with other chemotherapies.

  • Key Use: Critical in curative regimens (e.g., testicular cancer with cisplatin/etoposide).

  • Side Effects: Pulmonary toxicity (fibrosis) in 10-20% of patients, dose-dependent; skin hyperpigmentation.

  • Limitations: Cumulative lung damage risk mandates strict dose monitoring.

  • Production: Derived from Streptomyces verticillus; stabilized as sulfate salt for clinical use.

  • Research: Investigated in novel delivery systems (e.g., electrochemotherapy) to reduce toxicity.

Extended Summary

Bleomycin sulfate is a sulfur-containing glycopeptide antibiotic isolated from the bacterium Streptomyces verticillus. As a cytotoxic agent, it disrupts DNA synthesis by binding to Fe2? ions, generating reactive oxygen species (ROS) that cleave DNA strands. Clinically, it is administered via injection and is integral to combination therapies, such as BEP regimen (bleomycin, etoposide, cisplatin) for testicular cancer.

While effective, its use is constrained by pulmonary fibrosis, a potentially fatal side effect linked to cumulative doses exceeding 400,000 IU. Patients undergo regular pulmonary function tests during treatment. To mitigate toxicity, research focuses on localized delivery methods (e.g., intralesional injection for warts) and biomarkers to predict susceptibility.

Bleomycin remains irreplaceable in certain cancers due to its unique mechanism, but alternatives like immunotherapy are being explored for long-term safety.

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Company Profile Introduction

Wuhan Fortuna Chemical Co.,Ltd established in 2006, is a big integrative chemical enterprise being engaged in Pharmaceutical & its intermediates, Food/Feed additives, Fine chemicals in distributing the products of our own company and affiliated enterprises, are the members of Hubei E-commerce Chamber. Our company has professional persons who major in chemical R&D and sicentific management, supply fine chemical products with high quality and close service, also supply custom-tailored products according to our clients' requirement. We have a positive and self-motivated management work team with a common philosophy, caring and commitment through teamwork, our team strive to achieve success in delighting our clients and ourselves. Since Wuhan Fortuna Chemical Co., Ltd founded, we continuously innovate our products and improve our service, sales network. Hence, we initiate the first sale mode on net in China, which is the retail trade of small package bring along wholesale of diversified management modes. Our products are exported widely to South Korea, Vietnam, Australia, Europe and South America, highly recommended by our clients.We insist on the management creed “Market is our compass, Quality is our life, Credit is our soul”. Clients’ trust is our forward powder, their satisfaction is our struggling goal.

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  • Since: 2006-04-03
  • Address: Room 2015, No.2 Building Kaixin Mansion, No.107 Jinqiao Ave, Wuhan, China
INQUIRY
Betty Shu
+86-13986145403
info@fortunachem.com