Product Details
| Product Name:
AS1269574 |
CAS No.:
330981-72-1 |
| Purity:
99.99% |
Supply Ability:
10g |
| Release date:
2024/11/18 |
Product Introduction
Bioactivity
| Name | AS1269574 |
| Description | AS1269574 (AS 1269574) is a potent, orally available GPR119 agonist with potential for type 2 diabetes research. |
| In vitro | AS1269574 had an EC(50) value of 2.5μM in HEK293 cells transiently expressing human GPR119 and enhanced insulin secretion in the mouse pancreatic β-cell line MIN-6 only under high-glucose (16.8mM) conditions.?This contrasted with the action of the sulfonylurea glibenclamide, which also induced insulin secretion under low-glucose conditions (2.8mM)[1]. |
| In vivo | In in vivo studies, a single administration of AS1269574 to normal mice reduced blood glucose levels after oral glucose loading based on the observed insulin secretion profiles.?Significantly, AS1269574 did not affect fed and fasting plasma glucose levels in normal mice.?AS1269574 represents a novel structural class of small molecule, orally administrable GPR119 agonists with GSIS and promising potential for the treatment of type 2 diabetes[1]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 250 mg/mL (811.24 mM), Sonication is recommended.
|
| Keywords | TRP Channel | G Protein-Coupled Receptor 119 | secretion | Inhibitor | type | cation | AS-1269574 | diabetes | insulin | inhibit | Transient receptor potential channels | glucose | GPR119 | AS1269574 | channels |
| Inhibitors Related | (+)-Camphor | Vincamine | Caffeic Acid | Monomethyl fumarate | (-)-Menthol | Camphor | Pregnenolone | Probenecid | 1,4-Cineole | Benzyl nicotinate | TUG-1375 | Methyl salicylate |
| Related Compound Libraries | 經(jīng)典已知活性庫(kù) | 疼痛相關(guān)化合物庫(kù) | 神經(jīng)信號(hào)分子庫(kù) | 膜蛋白靶向化合物庫(kù) | 抗糖尿病庫(kù) | NO PAINS 化合物庫(kù) | 口服活性化合物庫(kù) | 已知活性化合物庫(kù) | GPCR靶點(diǎn)分子庫(kù) | 離子通道庫(kù) |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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Recommended supplier
| Product name |
Price |
|
Suppliers |
Update time |
|
|
$/ |
|
Anhui Ruihan Technology Co., Ltd
|
2023-08-21 |
United States