Adrenalone hydrochloride NEW
| Price | $30 | $43 | $98 |
| Package | 50mg | 100mg | 500mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-04-27 |
Product Details
| Product Name: Adrenalone hydrochloride | CAS No.: 62-13-5 |
| Purity: 99.91% | Supply Ability: 10g |
| Release date: 2025/04/27 |
Product Introduction
Bioactivity
| Name | Adrenalone hydrochloride |
| Description | Adrenalone hydrochloride (Adrenalone HCl) is a dopamine β-oxidase inhibitor with a similar structure to the norepinephrine transporter (NET) ligand, with an IC50 of 36.9 μM. It is an adrenergic agonist that acts as a local vasoconstrictor and hemostatic agent. |
| In vitro | Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively. |
| In vivo | Adrenalone is the ketone form of adrenaline, which is used as a topical hemostatic agent, vasoconstrictor, and nasal vasoconstrictor. In a nitrogenated aqueous solution containing 10 or 100 mM tert-butanol, Adrenalone (0.1 mM) reduces Adrenalone by hydration of electrons, resulting in the same transient spectrum, and thus all OH radicals are scavenged. Although Adrenalone acted similarly to carbonyl compounds in the reduction process, it was mainly controlled by catechol functional groups in the oxidation reaction. Adrenalone (12 μM) inhibited the conversion of dopamine to norepinephrine by inhibiting dopamine β-oxidase. Unlike Epinine, which has a keto group in the β-site, Adrenalone contains an amine group (ionic bond with Asp75), an aromatic ring (hydrophobic interactions with Tyr152, Phe72, and Phe317), and a hydroxyl group (hydrogen bonding with Ala145).10 μM and 100 μM Adrenalone 10 μM and 100 μM Adrenalone reduced substrate uptake by 99% and 27%, respectively. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 60 mg/mL (275.67 mM), Sonication is recommended. H2O : 40 mg/mL (183.78 mM), Sonication is recommended. |
| Keywords | α1-adrenergic receptor | Tyrosine | Syk | Src | signaling | Pyroptosis | Potassium | Piceatannol | PAR | kinase | Inhibitor | inhibit | Inflammation | Inflammasome | GPVI | Beta Receptor | AdrenergicReceptor | Adrenergic Receptor | Adrenalone hydrochloride | Adrenalone Hydrochloride | Adrenalone |
| Inhibitors Related | Olanzapine | Mirtazapine | Octopamine hydrochloride | Gemfibrozil | Buflomedil hydrochloride | Dexmedetomidine hydrochloride | Phenylephrine hydrochloride | Amitriptyline hydrochloride | Isoprenaline hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Doxepin hydrochloride |
Company Profile Introduction
TargetMol Chemicals Inc. is headquartered in Boston, MA, and specializes in products and services that serve the research needs of chemical and biological scientists worldwide. With a client base in 40+ countries, TargetMol has evolved into one of the biggest global research suppliers for compound libraries and small molecule compounds.
170+ Compound Libraries， 10000+ Noval Small Molecucles，16000+ Nature Compounds
TargetMol diligently updates and offers over 170 types of compound libraries and a wide range of high-quality research chemicals, including inhibitors, activators, natural products, peptides, antibodies , and novel life-science kits for laboratory and scientific use. In addition, our lab allows us to conduct CADD (computer-aided drug design) and chemical synthesis to meet the customization needs of our clients.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, Massachusetts, USA
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