Ac-YVAD-CMK NEW
| Price | $64 | $228 | $372 |
| Package | 1mg | 5mg | 10mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-05-30 |
Product Details
| Product Name: Ac-YVAD-CMK | CAS No.: 178603-78-6 |
| Purity: 99.49% | Supply Ability: 10g |
| Release date: 2025/05/30 |
Product Introduction
Bioactivity
| Name | Ac-YVAD-CMK |
| Description | Ac-YVAD-CMK (Ac-Tyr-Val-Ala-Asp-CMK) is a selective and irreversible inhibitor of Caspase-1 and inhibits pyroptosis, IL-1β and IL-18. Ac-YVAD-CMK shows neuroprotective and anti-inflammatory capacity. |
| In vitro | Ac-YVAD-cmk (40 and 80 μM) reduces the expression of IL-1β and IL-18 in activated microglia[3]. |
| In vivo | In SD rats, Ac-YVAD-cmk treatment (1 μg; injection into the left lateral ventricle) significantly decreases the protein levels of caspase-1 and mature IL-1β/IL-18 compared with the ICH group[3]. Ac-YVAD-cmk (12.5 μmol/kg) significantly reduces mortality from 83 to 33% in rats[4]. |
| Storage | store at low temperature,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO : 90 mg/mL (166.4 mM), Sonication is recommended. DMF : 10 mg/mL (18.48 mM), Sonication is recommended. |
| Keywords | Pyroptosis | Inflammationrelated | Inflammation related | inflammation | Immunologyrelated | Immunology related | ILReceptor | IL-1β | IL Receptor | Caspase-1 | Ac-YVAD-CMK |
| Inhibitors Related | Benzyl cinnamate | Disulfiram | Inosine pranobex | Amlexanox | Dexamethasone acetate | Bergenin | Dexamethasone | (Iso)-Z-VAD(OMe)-FMK | α-Terpineol | Tauroursodeoxycholate | Linalool | Apilimod |
| Related Compound Libraries | Apoptosis Compound Library | Cysteine Covalent Library | Bioactive Compound Library | Cytokine Inhibitor Library | Membrane Protein-targeted Compound Library | Protease Inhibitor Library | Neuroprotective Compound Library | Inhibitor Library | Anti-Aging Compound Library | Immunology/Inflammation Compound Library | Bioactive Compounds Library Max | Covalent Inhibitor Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
You may like
Recommended supplier
| Product name | Price | Suppliers | Update time | |
|---|---|---|---|---|
| $0.00/50mg |
VIP1Y
|
TargetMol Chemicals Inc.
|
2025-05-16 | |
| $1.10/1g |
VIP5Y
|
Shaanxi Dideu Medichem Co. Ltd
|
2021-05-13 | |
| $1.00/1g |
VIP5Y
|
RongNa Biotechnology Co.,Ltd
|
2024-03-26 |
United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
INQUIRY