9-amino-CPT NEW
| Price | $35 | $48 | $93 |
| Package | 1mg | 2mg | 5mg |
| Min. Order: | |
| Supply Ability: | 10g |
| Update Time: | 2025-07-24 |
Product Details
| Product Name: 9-amino-CPT | CAS No.: 91421-43-1 |
| Purity: 97.76% | Supply Ability: 10g |
| Release date: 2025/07/24 |
Product Introduction
Bioactivity
| Name | 9-amino-CPT |
| Description | 9-amino-CPT (Aminocamptothecin) is an inhibitor of topoisomerase I with potent anticancer activity. |
| In vitro | 9-amino-CPT inhibits PC-3, PC-3M, DU145, and LNCaP cells with IC50 values of 34.1, 10, 6.5, and 8.9 nM, respectively after 96 h of drug exposure [1]. In human bladder (MGH-U1), breast (MCF-7), and colon (HT-29) cancer cell lines, 9-amino-CPT cytotoxicity increases with both higher drug concentrations and longer exposure times. Minimal cell killing is also observed unless 9-amino-CPT concentrations exceed a threshold of 2.7 nM [2]. |
| In vivo | 9-amino-CPT inhibits tumor growth at the lowest oral dose (0.35 mg/kg/day), whereas higher oral doses (0.75 and 1 mg/kg/day) and s.c. administration (4 mg/kg/week) causes tumor regression [1]. 9-amino-CPT induces complete remissions in 55 % of SCID mice engrafted with human myeloid leukemia. The oral and intravenous routes are equally effective [3]. |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO : 3.33 mg/mL (9.16 mM), Sonication is recommended. |
| Keywords | Topoisomerase | Topo I | Inhibitor | inhibit | 9-amino-CPT | 9aminoCPT | 9-amino-2camptothecin | 9 amino CPT |
| Inhibitors Related | Berberine chloride | EIDD-1931 | Levofloxacin hydrochloride | Norfloxacin | Prulifloxacin | Ciprofloxacin | 1,4-Naphthoquinone | Ciprofloxacin monohydrochloride | Ofloxacin | Levofloxacin | Etoposide | Cholesteryl Hemisuccinate |
| Related Compound Libraries | Anti-Tumor Natural Product Library | Traditional Chinese Medicine Monomer Library | Alkaloid Natural Product Library | Selected Plant-Sourced Compound Library | Anti-Cancer Clinical Compound Library | Drug Repurposing Compound Library | Natural Product Library | Inhibitor Library | Bioactive Compounds Library Max | Heat-Clearing and Detoxifying Traditional Chinese Medicine Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Drug Library |
Company Profile Introduction
Target Molecule Corp. (TargetMol) is a global high-tech enterprise, headquartered in Boston, MA, specializing in chemical and biological research product and service to meet the research needs of global customers.
TargetMol has evolved into one of the biggest global compound library and small molecule suppliers and a customer based on 40+ countries. TargetMol offers over 80 types of compound libraries and a wide range of high-quality research chemicals including inhibitors, activator, natural compounds, peptides, inhibitory antibodies, and novel life-science kits, for laboratory and scientific use. Besides, virtual screening service is also available for customers who would like to conduct the computer-aided drug discovery.
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United States- Since: 2011-01-07
- Address: 36 Washington Street, Wellesley Hill, MA
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