EPISILVESTROL
| 中文名稱 | EPISILVESTROL |
|---|---|
| 中文同義詞 | 5MYC-UTR-LUC抑制劑(EPISILVESTROL);化合物 T11215 |
| 英文名稱 | Episilvestrol |
| 英文同義詞 | Episilvestrol;(1R,2R,3S,3aR,8bS)-6-[[(2S,3R,6R)-6-[(1S)-1,2-Dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxylic acid methyl ester;1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S,3R,6R)-6-[(1S)-1,2-dihydroxyethyl]-3-methoxy-1,4-dioxan-2-yl]oxy]-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R,2R,3S,3aR,8bS)- |
| CAS號(hào) | 697235-39-5 |
| 分子式 | C34H38O13 |
| 分子量 | 654.66 |
| EINECS號(hào) | |
| 相關(guān)類別 | 蛋白酪氨酸激酶;細(xì)胞生物學(xué)試劑 |
| Mol文件 | 697235-39-5.mol |
| 結(jié)構(gòu)式 |  |
EPISILVESTROL 性質(zhì)
| 沸點(diǎn) | 800.8±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.45±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 11.57±0.70(Predicted) |
| 顏色 | 白色至米白色 |
Episilvestrol 是 silvestrol 的衍生物，從 Aglaia silvestris 中分到，能夠抑制 eIF4A 靶作用的轉(zhuǎn)錄過(guò)程。
eIF4A
Episilvestrol is a specific eIF4A-targeting translation inhibitor, with antitumor activity. Episilvestrol is cytotoxic activity against several human cancer cell lines, such as Lu1, LNCaP, MCF-7 and HUVEC cells, with ED 50 s of 3.8, 3.8, 5.5 and 15.3 nM, respectively. The GI 50 s of Episilvestrol against the cell proliferation of NCI-H460 and MCF-7 cels are 17.96 nM and 17.96 nM after first test and 15.6 nM and 18.7 nM after 2 months via SRB assay. Episilvestrol also suppresses HK1 cells and EBV-positive C666.1 NPC cells.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/02/08 | HY-15359 | EPISILVESTROL Episilvestrol | 697235-39-5 | 1mg | 4000元 |
| 2023/10/26 | HY-15359 | EPISILVESTROL Episilvestrol | 697235-39-5 | 10 mM * 1 mLin DMSO | 71292元 |