Pomalidomide-NH-PEG3-azide

Pomalidomide-NH-PEG3-azide Suppliers list

Company Name:	Jilin Chinese Academy of Sciences-yanshen Technology
Tel:	+undefined18143011203
Email:	info@chemextension.com
Products Intro:	Product Name:4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione CAS:2271036-46-3 Purity:95%+ Package:1g;5g;10g;25g;50g;100g; Remarks:accept Custom Synthesis Services, support large packing

Company Name:	Xian confluore Biological Technology Co., Ltd.
Tel:	+86-15680926068 +86-15680926068
Email:	1924344760@confluore.cn
Products Intro:	Product Name:Pomalidomide-NH-PEG3-azide CAS:2271036-46-3 Purity:>98.00% Package:100mg

Company Name:	SHANGHAI FDC-CHEMICAL CO.,LTD
Tel:	021-61469567 13482353728
Email:	sales@fdc-chemical.com
Products Intro:	Product Name:4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione CAS:2271036-46-3 Purity:95% Package:1g

Company Name:	Xi'an Confluore Biological Technology Co., Ltd.
Tel:	+86-156-80926068 +86-15680926068
Email:	1924344760@qq.com
Products Intro:	Product Name:Pomalidomide-NH-PEG3-azide CAS:2271036-46-3 Purity:98% HPLC Package:10MG;25MG;50MG;100MG;1G;5G

Company Name:	Jilin Province Woda Biotechnology Co., Ltd.
Tel:	13504435624
Email:	1927928688@qq.com
Products Intro:	Product Name:Pomalidomide-NH-PEG3-azide CAS:2271036-46-3 Purity:99% HPLC Package:1克;5克;

Pomalidomide-NH-PEG3-azide manufacturers

Pomalidomide-NH-PEG3-azide Basic information

Product Name:	Pomalidomide-NH-PEG3-azide
Synonyms:	Pomalidomide-NH-PEG3-azide;IUN-36463;4-((2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;Pomalidomide 4'-PEG3-azide;1H-Isoindole-1,3(2H)-dione, 4-[[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione
CAS:	2271036-46-3
MF:	C21H26N6O7
MW:	474.47
EINECS:
Product Categories:
Mol File:	2271036-46-3.mol

Pomalidomide-NH-PEG3-azide Chemical Properties

form	Solid
color	Light yellow to yellow

Safety Information

HS Code

2933998090

MSDS Information

Pomalidomide-NH-PEG3-azide Usage And Synthesis

Uses	Pomalidomide 4'-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4'-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1?degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4'-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
IC 50	Cereblon
storage	Store at -20°C
References	[1] Shuai Wang, et al. Uncoupling of PARP1 trapping and inhibition using selective PARP1 degradation. Nat Chem Biol. 2019 Dec;15(12):1223-1231. DOI:10.1038/s41589-019-0379-2

Pomalidomide-NH-PEG3-azide Preparation Products And Raw materials

Tag:Pomalidomide-NH-PEG3-azide(2271036-46-3) Related Product Information

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